ENZYME entry: EC 3.4.21.75
Accepted Name |
furin.
|
Alternative Name(s) |
dibasic processing enzyme. |
paired basic amino acid residue cleaving enzyme. |
prohormone convertase. |
Reaction catalysed |
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors |
Comment(s) |
- Activated by calcium.
- Belongs to peptidase family S8.
|
Cross-references |
BRENDA | 3.4.21.75 |
EC2PDB | 3.4.21.75 |
ExplorEnz | 3.4.21.75 |
PRIAM enzyme-specific profiles | 3.4.21.75 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.75 |
IUBMB Enzyme Nomenclature | 3.4.21.75 |
IntEnz | 3.4.21.75 |
MEDLINE | Find literature relating to 3.4.21.75 |
MetaCyc | 3.4.21.75 |
Rhea expert-curated reactions | 3.4.21.75 |
UniProtKB/Swiss-Prot |
|
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