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ENZYME entry: EC 3.4.21.75

Accepted Name
Furin.
Alternative Name(s)
Dibasic processing enzyme.
Paired basic amino acid residue cleaving enzyme.
Prohormone convertase.
Reaction catalysed
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
Comment(s)
  • Activated by calcium.
  • Belongs to peptidase family S8.
Cross-references
PROSITEPDOC00125
BRENDA3.4.21.75
EC2PDB3.4.21.75
ExplorEnz3.4.21.75
PRIAM enzyme-specific profiles3.4.21.75
KEGG Ligand Database for Enzyme Nomenclature3.4.21.75
IUBMB Enzyme Nomenclature3.4.21.75
IntEnz3.4.21.75
MEDLINEFind literature relating to 3.4.21.75
MetaCyc3.4.21.75
Rhea expert-curated reactions3.4.21.75
UniProtKB/Swiss-Prot
A0A044RE18, BLI_ONCVO;  P26016, FUR11_DROME;  P30430, FUR1C_DROME;  
P30432, FUR2_DROME;  P29119, FURI1_XENLA;  Q28193, FURIN_BOVIN;  
P09958, FURIN_HUMAN;  P23188, FURIN_MOUSE;  P23377, FURIN_RAT;  

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