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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 3.4.21.78
| Accepted Name |
|---|
| Granzyme A.
|
| Alternative Name(s) |
|---|
| Cytotoxic T-lymphocyte proteinase 1. |
| Reaction catalysed |
|---|
| Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates |
| Comment(s) |
|---|
- From cytotoxic T lymphocyte granules.
- The human enzyme does not cleave Phe-|-Xaa.
- Belongs to peptidase family S1.
|
| Cross-references |
|---|
| PROSITE | PDOC00124 |
| BRENDA | 3.4.21.78 |
| EC2PDB | 3.4.21.78 |
| ExplorEnz | 3.4.21.78 |
| PRIAM enzyme-specific profiles | 3.4.21.78 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.78 |
| IUBMB Enzyme Nomenclature | 3.4.21.78 |
| IntEnz | 3.4.21.78 |
| MEDLINE | Find literature relating to 3.4.21.78 |
| MetaCyc | 3.4.21.78 |
| UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-