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ENZYME entry: EC 3.4.21.78
Accepted Name |
granzyme A.
|
Alternative Name(s) |
cytotoxic T-lymphocyte proteinase 1. |
Reaction catalysed |
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa- in small molecule substrates |
Comment(s) |
- From cytotoxic T lymphocyte granules.
- The human enzyme does not cleave Phe-|-Xaa.
- Belongs to peptidase family S1.
|
Cross-references |
BRENDA | 3.4.21.78 |
EC2PDB | 3.4.21.78 |
ExplorEnz | 3.4.21.78 |
PRIAM enzyme-specific profiles | 3.4.21.78 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.78 |
IUBMB Enzyme Nomenclature | 3.4.21.78 |
IntEnz | 3.4.21.78 |
MEDLINE | Find literature relating to 3.4.21.78 |
MetaCyc | 3.4.21.78 |
Rhea expert-curated reactions | 3.4.21.78 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-