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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.4.21.78

Accepted Name
Granzyme A.
Alternative Name(s)
Cytotoxic T-lymphocyte proteinase 1.
Reaction catalysed
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|-Xaa-in small molecule substrates
Comment(s)
  • From cytotoxic T lymphocyte granules.
  • The human enzyme does not cleave Phe-|-Xaa.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.78
EC2PDB3.4.21.78
ExplorEnz3.4.21.78
PRIAM enzyme-specific profiles3.4.21.78
KEGG Ligand Database for Enzyme Nomenclature3.4.21.78
IUBMB Enzyme Nomenclature3.4.21.78
IntEnz3.4.21.78
MEDLINEFind literature relating to 3.4.21.78
MetaCyc3.4.21.78
UniProtKB/Swiss-Prot
Q7YRZ7, GRAA_BOVIN;  P12544, GRAA_HUMAN;  P11032, GRAA_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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