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ENZYME

ENZYME entry: EC 3.4.21.89

Accepted Name
signal peptidase I
Alternative Name(s)
bacterial leader peptidase I
phage-procoat-leader peptidase
SPase I
Reaction catalysed
Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins
Comment(s)
  • Unaffected by inhibitors of most serine peptidases, but site-directed mutagenesis implicates a Ser/Lys catalytic dyad in activity.
  • Cleaves a single bond -Ala-|-Ala- in M13 phage procoat protein, producing free signal peptide and coat protein.
  • Eukaryote signal peptidases that may have somewhat different specificity are known from the endoplasmic reticulum membrane and mitochondrial inner membrane.
  • Belongs to peptidase family S26.
  • Formerly EC 3.4.99.36.
Cross-references
BRENDA3.4.21.89
EC2PDB3.4.21.89
ExplorEnz3.4.21.89
KEGG Ligand Database for Enzyme Nomenclature3.4.21.89
IUBMB Enzyme Nomenclature3.4.21.89
MEDLINEFind literature relating to 3.4.21.89
MetaCyc3.4.21.89
Rhea expert-curated reactions3.4.21.89
UniProtKB/Swiss-Prot
P41026, LEP1_BACAMP72660, LEP1_SYNY3P41025, LEP2_BACAM
P73157, LEP2_SYNY3P37943, LEPP_BACNAQ57350, LEPQ_BACNA
P28628, LEPS_BACSUP71013, LEPT_BACSUP42959, LEPU_BACSU
O07560, LEPV_BACSUP54506, LEPW_BACSUO67088, LEP_AQUAE
P41027, LEP_BACCLP42668, LEP_BACLIP57347, LEP_BUCAI
Q8K9R0, LEP_BUCAPQ89AM6, LEP_BUCBPP00803, LEP_ECOLI
P44454, LEP_HAEINQ9ZLQ5, LEP_HELPJO25300, LEP_HELPY
Q51876, LEP_LEPLMO33021, LEP_MYCLEP9WKA0, LEP_MYCTO
P9WKA1, LEP_MYCTUQ9I5G7, LEP_PSEAEP26844, LEP_PSEFL
A8GM78, LEP_RICAHA8GYE1, LEP_RICB8Q1RHA1, LEP_RICBR
A8EXI2, LEP_RICCKQ92JB1, LEP_RICCNQ4UKA7, LEP_RICFE
A8F0M1, LEP_RICM5Q9ZE32, LEP_RICPRA8GQT7, LEP_RICRS
Q8L2J7, LEP_RICTYP0A1W3, LEP_SALTIP0A1W2, LEP_SALTY
Q5HHB9, LEP_STAACP0A067, LEP_STAAMP0A068, LEP_STAAN
Q6GIC3, LEP_STAARQ6GAW1, LEP_STAASP0A070, LEP_STAAU
P0A069, LEP_STAAWO07344, LEP_STRPNP59662, LEP_STRR6
Q8H0W1, PLSP1_ARATHP67810, SC11A_BOVINP67811, SC11A_CANLF
P67812, SC11A_HUMANQ9R0P6, SC11A_MOUSEQ5R9C7, SC11A_PONAB
P42667, SC11A_RATP0C7V7, SC11B_HUMANP13679, SC11C_CANLF
Q9BY50, SC11C_HUMANQ9D8V7, SC11C_MOUSEQ5RC30, SC11C_PONAB
Q9WTR7, SC11C_RATF0UDD2, SEC11_AJEC8C0NKT8, SEC11_AJECG
C6HB29, SEC11_AJECHA6QX24, SEC11_AJECNC5G8L5, SEC11_AJEDR
D4ALL0, SEC11_ARTBCE4V4X0, SEC11_ARTGPC5FQ45, SEC11_ARTOC
A1CL29, SEC11_ASPCLB0XWT3, SEC11_ASPFCQ4WYF4, SEC11_ASPFU
Q2UBW3, SEC11_ASPORQ0CQC5, SEC11_ASPTNC5JJG5, SEC11_BLAGS
Q5A869, SEC11_CANALC4YNJ0, SEC11_CANAWB9WKT4, SEC11_CANDC
C5M4J6, SEC11_CANTTQ2H1P3, SEC11_CHAGBC4Y3D4, SEC11_CLAL4
C5PA33, SEC11_COCP7E9CXH2, SEC11_COCPSE3QXY4, SEC11_COLGM
Q6BP15, SEC11_DEBHAQ86JD4, SEC11_DICDIQ5B8K4, SEC11_EMENI
Q759W4, SEC11_EREGSC7ZHK5, SEC11_FUSV7F0XJH4, SEC11_GROCL
Q6CMR5, SEC11_KLULAC4QXP7, SEC11_KOMPGB0D4L0, SEC11_LACBS
C5DDH1, SEC11_LACTCE5A8D2, SEC11_LEPMJA5DS09, SEC11_LODEL
E9E796, SEC11_METAQE9F8V9, SEC11_METRAA1D6D8, SEC11_NEOFI
Q7RY44, SEC11_NEUCRE7R7C4, SEC11_OGAPDC1GU90, SEC11_PARBA
C1FYD2, SEC11_PARBDC0S3S0, SEC11_PARBPB6HC89, SEC11_PENRW
A5DIZ8, SEC11_PICGUA3LXS1, SEC11_PICSTQ8IE14, SEC11_PLAF7
B2B3T2, SEC11_PODANA4RGA1, SEC11_PYRO7B2WEL2, SEC11_PYRTR
E3RR70, SEC11_PYRTTD8Q7Q5, SEC11_SCHCMO74323, SEC11_SCHPO
A7E716, SEC11_SCLS1B6Q5G0, SEC11_TALMQB8M5K5, SEC11_TALSN
D4D5I1, SEC11_TRIVHD5GNC3, SEC11_TUBMMC4JYM4, SEC11_UNCRE
C9S8G0, SEC11_VERA1Q6CAG9, SEC11_YARLIB3LTI7, SEC11_YEAS1
C7GLT4, SEC11_YEAS2A6ZVU2, SEC11_YEAS7C8ZAS4, SEC11_YEAS8
E7KDY6, SEC11_YEASAE7Q587, SEC11_YEASBE7KQ01, SEC11_YEASL
P15367, SEC11_YEASTE7LVX4, SEC11_YEASVE7QG89, SEC11_YEASZ
C5E3W1, SEC11_ZYGRCO04348, TPP1_ARATHQ9M9Z2, TPP2_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.21.-
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