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ENZYME

ENZYME entry: EC 3.4.21.94

PURL: https://purl.expasy.org/enzyme/EC/3.4.21.94
Accepted Name
proprotein convertase 2
Alternative Name(s)
NEC 2
neuroendocrine convertase 2
PC2
prohormone convertase II
Reaction catalysed
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds
Comment(s)
  • A calcium dependent enzyme, maximally active at about pH 5.5.
  • Specificity is broader than that of prohormone convertase 1.
  • Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proinsulin and proluteinizing-hormone-releasing hormone.
  • Unlike prohormone convertase 1, does not cleave prorenin or prosomatostatin.
  • Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
  • Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 1.
  • Belongs to peptidase family S8.
Cross-references
BRENDA3.4.21.94
EC2PDB3.4.21.94
ExplorEnz3.4.21.94
KEGG Ligand Database for Enzyme Nomenclature3.4.21.94
IUBMB Enzyme Nomenclature3.4.21.94
MEDLINEFind literature relating to 3.4.21.94
MetaCyc3.4.21.94
Rhea expert-curated reactions3.4.21.94
UniProtKB/Swiss-Prot
Q9GLR0, NEC2_BOVING5ECN9, NEC2_CAEELQ9VBC7, NEC2_DROME
P16519, NEC2_HUMANP21661, NEC2_MOUSEQ03333, NEC2_PIG
Q5REC2, NEC2_PONABP28841, NEC2_RAT

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