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ENZYME entry: EC 3.4.21.94

Accepted Name
proprotein convertase 2.
Alternative Name(s)
NEC 2.
neuroendocrine convertase 2.
PC2.
prohormone convertase II.
Reaction catalysed
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds
Comment(s)
  • A calcium dependent enzyme, maximally active at about pH 5.5.
  • Specificity is broader than that of prohormone convertase 1.
  • Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proinsulin and proluteinizing-hormone-releasing hormone.
  • Unlike prohormone convertase 1, does not cleave prorenin or prosomatostatin.
  • Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
  • Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 1.
  • Belongs to peptidase family S8.
Cross-references
BRENDA3.4.21.94
EC2PDB3.4.21.94
ExplorEnz3.4.21.94
PRIAM enzyme-specific profiles3.4.21.94
KEGG Ligand Database for Enzyme Nomenclature3.4.21.94
IUBMB Enzyme Nomenclature3.4.21.94
IntEnz3.4.21.94
MEDLINEFind literature relating to 3.4.21.94
MetaCyc3.4.21.94
Rhea expert-curated reactions3.4.21.94
UniProtKB/Swiss-Prot
Q9GLR0, NEC2_BOVIN;  G5ECN9, NEC2_CAEEL;  P16519, NEC2_HUMAN;  
P21661, NEC2_MOUSE;  Q03333, NEC2_PIG;  Q5REC2, NEC2_PONAB;  
P28841, NEC2_RAT;  

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