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ENZYME entry: EC

Accepted Name
proprotein convertase 2.
Alternative Name(s)
NEC 2.
neuroendocrine convertase 2.
prohormone convertase II.
Reaction catalysed
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds
  • A calcium dependent enzyme, maximally active at about pH 5.5.
  • Specificity is broader than that of prohormone convertase 1.
  • Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proinsulin and proluteinizing-hormone-releasing hormone.
  • Unlike prohormone convertase 1, does not cleave prorenin or prosomatostatin.
  • Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
  • Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 1.
  • Belongs to peptidase family S8.
PRIAM enzyme-specific profiles3.4.21.94
KEGG Ligand Database for Enzyme Nomenclature3.4.21.94
IUBMB Enzyme Nomenclature3.4.21.94
MEDLINEFind literature relating to
Rhea expert-curated reactions3.4.21.94
P21661, NEC2_MOUSE;  Q03333, NEC2_PIG;  Q5REC2, NEC2_PONAB;  
P28841, NEC2_RAT;  

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