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ENZYME entry: EC 3.4.21.95

Accepted Name
Snake venom factor V activator.
Alternative Name(s)
Factor V-activating proteinase.
RVV-V component.
Reaction catalysed
Fully activates human clotting factor V by a single cleavage at the 1545-Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2)
Comment(s)
  • Inhibited by diisopropyl fluorophosphate.
  • Belongs to peptidase family S1.
Cross-references
PROSITEPDOC00124
BRENDA3.4.21.95
EC2PDB3.4.21.95
ExplorEnz3.4.21.95
PRIAM enzyme-specific profiles3.4.21.95
KEGG Ligand Database for Enzyme Nomenclature3.4.21.95
IUBMB Enzyme Nomenclature3.4.21.95
IntEnz3.4.21.95
MEDLINEFind literature relating to 3.4.21.95
MetaCyc3.4.21.95
Rhea expert-curated reactions3.4.21.95
UniProtKB/Swiss-Prot
P18964, VSPA_DABSI;  Q9PT41, VSPF5_MACLB;  P18965, VSPG_DABSI;  

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