ENZYME entry: EC 3.4.21.95
Accepted Name |
Snake venom factor V activator.
|
Alternative Name(s) |
Factor V-activating proteinase. |
RVV-V component. |
Reaction catalysed |
Fully activates human clotting factor V by a single cleavage at the 1545-Trp-Tyr-Leu-Arg-|-Ser-Asn-Asn-Gly-1552 bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO(2) |
Comment(s) |
- Inhibited by diisopropyl fluorophosphate.
- Belongs to peptidase family S1.
|
Cross-references |
PROSITE | PDOC00124 |
BRENDA | 3.4.21.95 |
EC2PDB | 3.4.21.95 |
ExplorEnz | 3.4.21.95 |
PRIAM enzyme-specific profiles | 3.4.21.95 |
KEGG Ligand Database for Enzyme Nomenclature | 3.4.21.95 |
IUBMB Enzyme Nomenclature | 3.4.21.95 |
IntEnz | 3.4.21.95 |
MEDLINE | Find literature relating to 3.4.21.95 |
MetaCyc | 3.4.21.95 |
UniProtKB/Swiss-Prot |
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