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ENZYME entry: EC 3.4.24.18

Accepted Name
Meprin A.
Alternative Name(s)
Endopeptidase-2.
Reaction catalysed
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues
Cofactor(s)
Zn(2+).
Comment(s)
  • A membrane-bound metalloendopeptidase of rat and mouse kidney and intestinal brush borders, and salivary ducts.
  • Differences from EC 3.4.24.11 include insensitivity to phosphoramidon and thiorphan.
  • PABA-peptide hydrolase is a very similar enzyme found in human intestinal microvilli.
  • Belongs to peptidase family M12A.
Cross-references
PROSITEPDOC00129
BRENDA3.4.24.18
EC2PDB3.4.24.18
ExplorEnz3.4.24.18
PRIAM enzyme-specific profiles3.4.24.18
KEGG Ligand Database for Enzyme Nomenclature3.4.24.18
IUBMB Enzyme Nomenclature3.4.24.18
IntEnz3.4.24.18
MEDLINEFind literature relating to 3.4.24.18
MetaCyc3.4.24.18
Rhea expert-curated reactions3.4.24.18
UniProtKB/Swiss-Prot
Q16819, MEP1A_HUMAN;  P28825, MEP1A_MOUSE;  Q64230, MEP1A_RAT;  

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