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ENZYME

ENZYME entry: EC 3.5.1.60

PURL: https://purl.expasy.org/enzyme/EC/3.5.1.60
Accepted Name
N-(long-chain-acyl)ethanolamine deacylase
Alternative Name(s)
N-acylethanolamine amidohydrolase
Reaction catalysed
an N-(long-chain fatty acyl)ethanolamine + H2O = a long-chain fatty acid + ethanolamine
Comment(s)
  • This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower activity on other N-(long-chain-acyl)ethanolamines.
  • It is only active at acidic pH.
  • Unlike EC 3.5.1.99 it does not act on primary amides such as oleamide, and has only a marginal activity with anandamide.
  • The enzyme is translated as an inactive proenzyme, followed by autocatalytic cleavage into two subunits that reassociate to form an active heterodimeric complex.
Cross-references
BRENDA3.5.1.60
EC2PDB3.5.1.60
ExplorEnz3.5.1.60
KEGG Ligand Database for Enzyme Nomenclature3.5.1.60
IUBMB Enzyme Nomenclature3.5.1.60
MEDLINEFind literature relating to 3.5.1.60
MetaCyc3.5.1.60
Rhea expert-curated reactions3.5.1.60
UniProtKB/Swiss-Prot
Q9GUI1, NAAA_CAEELH0VCJ6, NAAA_CAVPOQ02083, NAAA_HUMAN
Q9D7V9, NAAA_MOUSEG1T7U7, NAAA_RABITQ5KTC7, NAAA_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-