ENZYME entry: EC 3.5.1.60
Accepted Name |
N-(long-chain-acyl)ethanolamine deacylase.
|
Alternative Name(s) |
N-acylethanolamine amidohydrolase. |
Reaction catalysed |
N-(long-chain-acyl)ethanolamine + H(2)O <=> a long-chain carboxylate + ethanolamine |
Comment(s) |
- This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower
activity on other N-(long-chain-acyl)ethanolamines.
- It is only active at acidic pH.
- Unlike EC 3.5.1.99 it does not act on primary amides such as
oleamide, and has only a marginal activity with anandamide.
- The enzyme is translated as an inactive proenzyme, followed by
autocatalytic cleavage into two subunits that reassociate to form an
active heterodimeric complex.
|
Cross-references |
BRENDA | 3.5.1.60 |
EC2PDB | 3.5.1.60 |
ExplorEnz | 3.5.1.60 |
PRIAM enzyme-specific profiles | 3.5.1.60 |
KEGG Ligand Database for Enzyme Nomenclature | 3.5.1.60 |
IUBMB Enzyme Nomenclature | 3.5.1.60 |
IntEnz | 3.5.1.60 |
MEDLINE | Find literature relating to 3.5.1.60 |
MetaCyc | 3.5.1.60 |
Rhea expert-curated reactions | 3.5.1.60 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
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