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ENZYME entry: EC 3.5.1.60

Accepted Name
N-(long-chain-acyl)ethanolamine deacylase.
Alternative Name(s)
N-acylethanolamine amidohydrolase.
Reaction catalysed
H2O + N-(long-chain fatty acyl)ethanolamine <=> a long-chain fatty acid + ethanolamine
Comment(s)
  • This lysosomal enzyme acts best on palmitoyl ethanolamide, with lower activity on other N-(long-chain-acyl)ethanolamines.
  • It is only active at acidic pH.
  • Unlike EC 3.5.1.99 it does not act on primary amides such as oleamide, and has only a marginal activity with anandamide.
  • The enzyme is translated as an inactive proenzyme, followed by autocatalytic cleavage into two subunits that reassociate to form an active heterodimeric complex.
Cross-references
BRENDA3.5.1.60
EC2PDB3.5.1.60
ExplorEnz3.5.1.60
PRIAM enzyme-specific profiles3.5.1.60
KEGG Ligand Database for Enzyme Nomenclature3.5.1.60
IUBMB Enzyme Nomenclature3.5.1.60
IntEnz3.5.1.60
MEDLINEFind literature relating to 3.5.1.60
MetaCyc3.5.1.60
Rhea expert-curated reactions3.5.1.60
UniProtKB/Swiss-Prot
Q9GUI1, NAAA_CAEEL;  H0VCJ6, NAAA_CAVPO;  Q02083, NAAA_HUMAN;  
Q9D7V9, NAAA_MOUSE;  G1T7U7, NAAA_RABIT;  Q5KTC7, NAAA_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
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