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ENZYME

ENZYME entry: EC 3.5.1.77

PURL: https://purl.expasy.org/enzyme/EC/3.5.1.77
Accepted Name
N-carbamoyl-D-amino-acid hydrolase
Alternative Name(s)
D-N-carbamoylase
N-carbamoylase
N-carbamoyl-D-amino acid hydrolase
Reaction catalysed
an N-carbamoyl-D-amino acid + H2O + 2 H(+) = a D-alpha-amino acid + NH4(+) + CO2
Comment(s)
  • This enzyme, along with EC 3.5.1.87, EC 5.1.99.5 and EC 3.5.2.2, forms part of the reaction cascade known as the 'hydantoinase process', which allows the total conversion of D,L-5-monosubstituted hydantoins into optically pure D- or L-amino acids.
  • Has strict stereospecificity for N-carbamoyl-D-amino acids and does not act upon the corresponding L-amino acids or N-formyl amino acids, N-carbamoyl-sarcosine, -citrulline, -allantoin and -ureidopropanoate, which are substrates for other amidohydrolases.
Cross-references
BRENDA3.5.1.77
EC2PDB3.5.1.77
ExplorEnz3.5.1.77
KEGG Ligand Database for Enzyme Nomenclature3.5.1.77
IUBMB Enzyme Nomenclature3.5.1.77
MEDLINEFind literature relating to 3.5.1.77
MetaCyc3.5.1.77
Rhea expert-curated reactions3.5.1.77
UniProtKB/Swiss-Prot
Q44185, DCAS_AGRRDP60327, DCAS_AGRSKQ5S260, DCAS_ENSAD

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-