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ENZYME entry: EC 3.5.99.10

Accepted Name
2-iminobutanoate/2-iminopropanoate deaminase.
Alternative Name(s)
enamine/imine deaminase.
Reaction catalysed
  • 2-iminobutanoate + H2O <=> 2-oxobutanoate + NH4(+)
  • 2-iminopropanoate + H2O <=> NH4(+) + pyruvate
Comment(s)
  • This enzyme, which has been found in all species and tissues examined, catalyzes the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19 and EC 4.3.1.17.
  • The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.
Cross-references
BRENDA3.5.99.10
EC2PDB3.5.99.10
ExplorEnz3.5.99.10
PRIAM enzyme-specific profiles3.5.99.10
KEGG Ligand Database for Enzyme Nomenclature3.5.99.10
IUBMB Enzyme Nomenclature3.5.99.10
IntEnz3.5.99.10
MEDLINEFind literature relating to 3.5.99.10
MetaCyc3.5.99.10
Rhea expert-curated reactions3.5.99.10
UniProtKB/Swiss-Prot
Q94JQ4, RIDA_ARATH;  P37552, RIDA_BACSU;  Q3T114, RIDA_BOVIN;  
P80601, RIDA_CAPHI;  A0A1J1DL12, RIDA_DERFA;  P0AF94, RIDA_ECOL6;  
P0AF93, RIDA_ECOLI;  P52758, RIDA_HUMAN;  P52760, RIDA_MOUSE;  
Q8U308, RIDA_PYRFU;  P52759, RIDA_RAT;  Q7CP78, RIDA_SALTY;  
P0AF95, RIDA_SHIFL;  

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