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ENZYME entry: EC 4.3.1.19

Accepted Name
threonine ammonia-lyase
Alternative Name(s)
L-serine dehydratase
L-threonine deaminase
L-threonine dehydratase
L-threonine hydro-lyase (deaminating)
serine deaminase
threonine deaminase
threonine dehydrase
threonine dehydratase
Reaction catalysed
L-threonine <=> 2-oxobutanoate + NH4(+)
Comment(s)
  • The reaction catalyzed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.16), followed by tautomerization to an imine form and hydrolysis of the C-N bond.
  • The latter reaction, which can occur spontaneously, is also be catalyzed by EC 3.5.99.10.
  • The enzymes from a number of sources also act on L-serine, cf. EC 4.3.1.17.
  • Formerly EC 4.2.1.16.
Cross-references
BRENDA4.3.1.19
EC2PDB4.3.1.19
ExplorEnz4.3.1.19
PRIAM enzyme-specific profiles4.3.1.19
KEGG Ligand Database for Enzyme Nomenclature4.3.1.19
IUBMB Enzyme Nomenclature4.3.1.19
IntEnz4.3.1.19
MEDLINEFind literature relating to 4.3.1.19
MetaCyc4.3.1.19
Rhea expert-curated reactions4.3.1.19
UniProtKB/Swiss-Prot
P37946, ILVA_BACSUP53607, ILVA_BURM1Q04513, ILVA_CORGL
P04968, ILVA_ECOLIP46493, ILVA_HAEINQ9KC63, ILVA_HALH5
Q02145, ILVA_LACLAP66898, ILVA_MYCBOQ9X7F1, ILVA_MYCLE
P9WG94, ILVA_MYCTOP9WG95, ILVA_MYCTUQ9CKJ2, ILVA_PASMU
P20506, ILVA_SALTYQ2FF63, ILVA_STAA3Q2FWJ9, ILVA_STAA8
Q2YUE8, ILVA_STAABQ5HEE0, ILVA_STAACQ99SJ1, ILVA_STAAM
Q7A4H2, ILVA_STAANQ3V7T5, ILVA_STAARQ3V7T4, ILVA_STAAS
Q8NVI8, ILVA_STAAWQ5HMF5, ILVA_STAEQQ8CNK9, ILVA_STAES
Q4L7U4, ILVA_STAHJQ49Z16, ILVA_STAS1Q0VCW4, SDHL_BOVIN
P20132, SDHL_HUMANQ8VBT2, SDHL_MOUSEP09367, SDHL_RAT
Q96GA7, SDSL_HUMANQ8R238, SDSL_MOUSEP25379, STDH_YEAST
A0FKE6, TD1_SOLLCP25306, TD2_SOLLCP0AGF8, TDCB_ECO57
P0AGF7, TDCB_ECOL6P0AGF6, TDCB_ECOLIP11954, TDCB_SALTY
P0AGF9, TDCB_SHIFLQ2FH01, TDCB_STAA3Q2FYJ3, TDCB_STAA8
Q2YY67, TDCB_STAABQ5HFY5, TDCB_STAACQ99U50, TDCB_STAAM
Q7A5L8, TDCB_STAANQ6GGX0, TDCB_STAARQ6G9C4, TDCB_STAAS
Q8NWQ4, TDCB_STAAWQ9AXU4, TD_NICATP31212, TD_SOLTU
Q9ZSS6, THD1_ARATHQ39469, THD1_CICARO42615, THDH_BLAAD
O94634, THDH_SCHPOP00927, THDH_YEASTQ74FW6, TSAL_GEOSL
Q9WYJ1, TSAL_THEMAP55664, Y4TJ_SINFN

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