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ENZYME

ENZYME entry: EC 4.3.1.19

PURL: https://purl.expasy.org/enzyme/EC/4.3.1.19
Accepted Name
threonine ammonia-lyase
Alternative Name(s)
L-serine dehydratase
L-threonine deaminase
L-threonine dehydratase
L-threonine hydro-lyase (deaminating)
serine deaminase
threonine deaminase
threonine dehydrase
threonine dehydratase
Reaction catalysed
L-threonine = 2-oxobutanoate + NH4(+)
Comment(s)
  • The reaction catalyzed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.16), followed by tautomerization to an imine form and hydrolysis of the C-N bond.
  • The latter reaction, which can occur spontaneously, is also be catalyzed by EC 3.5.99.10.
  • The enzymes from a number of sources also act on L-serine, cf. EC 4.3.1.17.
  • Formerly EC 4.2.1.16.
Cross-references
BRENDA4.3.1.19
EC2PDB4.3.1.19
ExplorEnz4.3.1.19
KEGG Ligand Database for Enzyme Nomenclature4.3.1.19
IUBMB Enzyme Nomenclature4.3.1.19
MEDLINEFind literature relating to 4.3.1.19
MetaCyc4.3.1.19
Rhea expert-curated reactions4.3.1.19
UniProtKB/Swiss-Prot
P37946, ILVA_BACSUP53607, ILVA_BURM1Q04513, ILVA_CORGL
P04968, ILVA_ECOLIP46493, ILVA_HAEINQ9KC63, ILVA_HALH5
Q02145, ILVA_LACLAP66898, ILVA_MYCBOQ9X7F1, ILVA_MYCLE
P9WG94, ILVA_MYCTOP9WG95, ILVA_MYCTUQ9CKJ2, ILVA_PASMU
P20506, ILVA_SALTYQ2FF63, ILVA_STAA3Q2FWJ9, ILVA_STAA8
Q2YUE8, ILVA_STAABQ5HEE0, ILVA_STAACQ99SJ1, ILVA_STAAM
Q7A4H2, ILVA_STAANQ3V7T5, ILVA_STAARQ3V7T4, ILVA_STAAS
Q8NVI8, ILVA_STAAWQ5HMF5, ILVA_STAEQQ8CNK9, ILVA_STAES
Q4L7U4, ILVA_STAHJQ49Z16, ILVA_STAS1Q0VCW4, SDHL_BOVIN
P20132, SDHL_HUMANQ8VBT2, SDHL_MOUSEP09367, SDHL_RAT
Q96GA7, SDSL_HUMANQ8R238, SDSL_MOUSEA0A6N3IN21, SDSL_RAT
P25379, STDH_YEASTA0FKE6, TD1_SOLLCP25306, TD2_SOLLC
P0AGF8, TDCB_ECO57P0AGF7, TDCB_ECOL6P0AGF6, TDCB_ECOLI
P11954, TDCB_SALTYP0AGF9, TDCB_SHIFLQ2FH01, TDCB_STAA3
Q2FYJ3, TDCB_STAA8Q2YY67, TDCB_STAABQ5HFY5, TDCB_STAAC
Q99U50, TDCB_STAAMQ7A5L8, TDCB_STAANQ6GGX0, TDCB_STAAR
Q6G9C4, TDCB_STAASQ8NWQ4, TDCB_STAAWQ9AXU4, TD_NICAT
P31212, TD_SOLTUQ9ZSS6, THD1_ARATHQ39469, THD1_CICAR
O42615, THDH_BLAADO94634, THDH_SCHPOP00927, THDH_YEAST
Q74FW6, TSAL_GEOSLQ9WYJ1, TSAL_THEMAP55664, Y4TJ_SINFN

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-