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ENZYME entry: EC 4.3.1.17

Accepted Name
L-serine ammonia-lyase.
Alternative Name(s)
L-hydroxyaminoacid dehydratase.
L-serine deaminase.
L-serine dehydratase.
L-serine hydro-lyase (deaminating).
Serine deaminase.
Reaction catalysed
L-serine <=> pyruvate + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate or iron-sulfur.
Comment(s)
  • The reaction catalyzed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13) followed by tautomerization to an imine form and hydrolysis of the C-N bond.
  • The latter reaction, which can occur spontaneously, is also be catalyzed by EC 3.5.99.10.
  • This reaction is also carried out by EC 4.3.1.19 from a number of sources.
  • Formerly EC 4.2.1.13.
Cross-references
PROSITEPDOC00149
BRENDA4.3.1.17
EC2PDB4.3.1.17
ExplorEnz4.3.1.17
PRIAM enzyme-specific profiles4.3.1.17
KEGG Ligand Database for Enzyme Nomenclature4.3.1.17
IUBMB Enzyme Nomenclature4.3.1.17
IntEnz4.3.1.17
MEDLINEFind literature relating to 4.3.1.17
MetaCyc4.3.1.17
Rhea expert-curated reactions4.3.1.17
UniProtKB/Swiss-Prot
P0CF23, SDH1_YEASX;  O34607, SDHAA_BACSU;  O34635, SDHAB_BACSU;  
P80212, SDHA_ANAPI;  Q48838, SDHA_LATSK;  P33073, SDHA_PEPAS;  
P80213, SDHB_ANAPI;  P33074, SDHB_PEPAS;  Q0VCW4, SDHL_BOVIN;  
Q86B06, SDHL_DICDI;  P16095, SDHL_ECOLI;  P71349, SDHL_HAEIN;  
Q9ZMU7, SDHL_HELPJ;  P56072, SDHL_HELPY;  P20132, SDHL_HUMAN;  
Q8VBT2, SDHL_MOUSE;  P66774, SDHL_MYCBO;  P9WGT4, SDHL_MYCTO;  
P9WGT5, SDHL_MYCTU;  P09367, SDHL_RAT;  O86564, SDHL_STRCO;  
B3LU13, SDHL_YEAS1;  B5VKE8, SDHL_YEAS6;  A6ZVB1, SDHL_YEAS7;  
C8ZAU6, SDHL_YEAS8;  P30744, SDHM_ECOLI;  Q96GA7, SDSL_HUMAN;  
Q8R238, SDSL_MOUSE;  Q2PGG3, SRR_ARATH;  A0JNI4, SRR_BOVIN;  
Q54HH2, SRR_DICDI;  Q9GZT4, SRR_HUMAN;  Q9QZX7, SRR_MOUSE;  
A2XWA9, SRR_ORYSI;  Q7XSN8, SRR_ORYSJ;  Q76EQ0, SRR_RAT;  
O59791, SRR_SCHPO;  P25379, STDH_YEAST;  P25306, TD2_SOLLC;  
P0AGF8, TDCB_ECO57;  P0AGF7, TDCB_ECOL6;  P0AGF6, TDCB_ECOLI;  
P11954, TDCB_SALTY;  P0AGF9, TDCB_SHIFL;  P42630, TDCG_ECOLI;  
Q74FW6, TSAL_GEOSL;  P0CF22, YI167_YEAST;  P0CF21, YI168_YEAST;  

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