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ENZYME

ENZYME entry: EC 4.3.1.17

Accepted Name
L-serine ammonia-lyase
Alternative Name(s)
L-hydroxyaminoacid dehydratase
L-serine deaminase
L-serine dehydratase
L-serine hydro-lyase (deaminating)
serine deaminase
Reaction catalysed
L-serine <=> NH4(+) + pyruvate
Comment(s)
  • The reaction catalyzed by both types of enzymes involves the initial elimination of water to form an enamine intermediate (hence the enzyme's original classification as EC 4.2.1.13) followed by tautomerization to an imine form and hydrolysis of the C-N bond.
  • The latter reaction, which can occur spontaneously, is also be catalyzed by EC 3.5.99.10.
  • This reaction is also carried out by EC 4.3.1.19 from a number of sources.
  • Formerly EC 4.2.1.13.
Cross-references
BRENDA4.3.1.17
EC2PDB4.3.1.17
ExplorEnz4.3.1.17
PRIAM enzyme-specific profiles4.3.1.17
KEGG Ligand Database for Enzyme Nomenclature4.3.1.17
IUBMB Enzyme Nomenclature4.3.1.17
IntEnz4.3.1.17
MEDLINEFind literature relating to 4.3.1.17
MetaCyc4.3.1.17
Rhea expert-curated reactions4.3.1.17
UniProtKB/Swiss-Prot
P0CF23, SDH1_YEASXO34607, SDHAA_BACSUO34635, SDHAB_BACSU
P80212, SDHA_ANAPIQ48838, SDHA_LATSKP33073, SDHA_PEPAS
P80213, SDHB_ANAPIP33074, SDHB_PEPASQ0VCW4, SDHL_BOVIN
Q86B06, SDHL_DICDIP16095, SDHL_ECOLIP71349, SDHL_HAEIN
Q9ZMU7, SDHL_HELPJP56072, SDHL_HELPYP20132, SDHL_HUMAN
Q8VBT2, SDHL_MOUSEP66774, SDHL_MYCBOP9WGT4, SDHL_MYCTO
P9WGT5, SDHL_MYCTUP09367, SDHL_RATO86564, SDHL_STRCO
B3LU13, SDHL_YEAS1B5VKE8, SDHL_YEAS6A6ZVB1, SDHL_YEAS7
C8ZAU6, SDHL_YEAS8P30744, SDHM_ECOLIQ96GA7, SDSL_HUMAN
Q8R238, SDSL_MOUSEQ2PGG3, SRR_ARATHA0JNI4, SRR_BOVIN
Q54HH2, SRR_DICDIQ9GZT4, SRR_HUMANQ9QZX7, SRR_MOUSE
A2XWA9, SRR_ORYSIQ7XSN8, SRR_ORYSJQ76EQ0, SRR_RAT
O59791, SRR_SCHPOP25379, STDH_YEASTP25306, TD2_SOLLC
P0AGF8, TDCB_ECO57P0AGF7, TDCB_ECOL6P0AGF6, TDCB_ECOLI
P11954, TDCB_SALTYP0AGF9, TDCB_SHIFLP42630, TDCG_ECOLI
Q74FW6, TSAL_GEOSLP0CF22, YI167_YEASTP0CF21, YI168_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-