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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.6.1.1

Accepted Name
Inorganic diphosphatase.
Alternative Name(s)
Diphosphate phosphohydrolase.
Inorganic pyrophosphatase.
Pyrophosphate phosphohydrolase.
Reaction catalysed
Diphosphate + H(2)O <=> 2 phosphate
Comment(s)
  • Specificity varies with the source and with the activating metal ion.
  • The enzyme from some sources may be identical with EC 3.1.3.1 or EC 3.1.3.9.
Cross-references
PROSITEPDOC00325
BRENDA3.6.1.1
EC2PDB3.6.1.1
ExplorEnz3.6.1.1
PRIAM enzyme-specific profiles3.6.1.1
KEGG Ligand Database for Enzyme Nomenclature3.6.1.1
IUBMB Enzyme Nomenclature3.6.1.1
IntEnz3.6.1.1
MEDLINEFind literature relating to 3.6.1.1
MetaCyc3.6.1.1
UniProtKB/Swiss-Prot
Q93V56, IPYR1_ARATH;  Q93Y52, IPYR1_CHLRE;  Q889M7, IPYR1_PSESM;  
P21216, IPYR2_ARATH;  Q949J1, IPYR2_CHLRE;  Q9H2U2, IPYR2_HUMAN;  
Q91VM9, IPYR2_MOUSE;  Q87WD6, IPYR2_PSESM;  P87118, IPYR2_SCHPO;  
P28239, IPYR2_YEAST;  O82793, IPYR3_ARATH;  Q9LFF9, IPYR4_ARATH;  
O82597, IPYR5_ARATH;  Q9LXC9, IPYR6_ARATH;  Q9YBA5, IPYR_AERPE;  
Q8UC37, IPYR_AGRFC;  O67501, IPYR_AQUAE;  Q8GQS5, IPYR_AQUPY;  
Q757J8, IPYR_ASHGO;  Q9KCG7, IPYR_BACHD;  P19514, IPYR_BACP3;  
P51064, IPYR_BARBK;  P82992, IPYR_BLAVI;  P37980, IPYR_BOVIN;  
Q89WY0, IPYR_BRADU;  P65744, IPYR_BRUME;  P65745, IPYR_BRUSU;  
P57190, IPYR_BUCAI;  Q8KA31, IPYR_BUCAP;  P59417, IPYR_BUCBP;  
Q18680, IPYR_CAEEL;  Q9PHM9, IPYR_CAMJE;  P83777, IPYR_CANAL;  
Q6FRB7, IPYR_CANGA;  Q9AC20, IPYR_CAUVC;  Q821T4, IPYR_CHLCV;  
Q9PLF1, IPYR_CHLMU;  Q9Z6Y8, IPYR_CHLPN;  B0B8Z8, IPYR_CHLT2;  
Q3KKS0, IPYR_CHLTA;  B0BAM7, IPYR_CHLTB;  O84777, IPYR_CHLTR;  
Q8XIQ9, IPYR_CLOPE;  Q8FMF8, IPYR_COREF;  Q8NM79, IPYR_CORGL;  
P80887, IPYR_CYAPA;  Q6BWA5, IPYR_DEBHA;  P19371, IPYR_DESVH;  
Q54PV8, IPYR_DICDI;  O77460, IPYR_DROME;  P0A7B0, IPYR_ECO57;  
Q8FAG0, IPYR_ECOL6;  P0A7A9, IPYR_ECOLI;  Q5B912, IPYR_EMENI;  
Q8SR69, IPYR_ENCCU;  P81987, IPYR_EUGGR;  O05724, IPYR_GEOSE;  
O05545, IPYR_GLUOX;  Q7VPC0, IPYR_HAEDU;  P44529, IPYR_HAEIN;  
Q9HSF3, IPYR_HALSA;  Q9ZLL5, IPYR_HELPJ;  P56153, IPYR_HELPY;  
O23979, IPYR_HORVV;  Q15181, IPYR_HUMAN;  P13998, IPYR_KLULA;  
O34955, IPYR_LEGPN;  Q6ACP7, IPYR_LEIXX;  Q72MG4, IPYR_LEPIC;  
Q8EZ21, IPYR_LEPIN;  Q4R543, IPYR_MACFA;  O48556, IPYR_MAIZE;  
Q8TMI3, IPYR_METAC;  Q8TVE2, IPYR_METKA;  Q8PWY5, IPYR_METMA;  
O26363, IPYR_METTH;  Q9D819, IPYR_MOUSE;  P65747, IPYR_MYCBO;  
P47593, IPYR_MYCGE;  O69540, IPYR_MYCLE;  Q8EVW9, IPYR_MYCPE;  
P75250, IPYR_MYCPN;  Q98Q96, IPYR_MYCPU;  P9WI54, IPYR_MYCTO;  
P9WI55, IPYR_MYCTU;  Q74MY6, IPYR_NANEQ;  Q9JVG3, IPYR_NEIMA;  
Q9K0G4, IPYR_NEIMB;  Q6MVH7, IPYR_NEUCR;  P80562, IPYR_NOSS1;  
P81988, IPYR_OCHDN;  A2X8Q3, IPYR_ORYSI;  Q0DYB1, IPYR_ORYSJ;  
P57918, IPYR_PASMU;  O13505, IPYR_PICPA;  Q6KZB3, IPYR_PICTO;  
O77392, IPYR_PLAF7;  Q5R8T6, IPYR_PONAB;  Q9HWZ6, IPYR_PSEAE;  
P58733, IPYR_PSEAO;  P0CAP8, IPYR_PSEGP;  Q88QF6, IPYR_PSEPK;  
Q9UY24, IPYR_PYRAB;  Q8U438, IPYR_PYRFU;  O59570, IPYR_PYRHO;  
Q8XWX1, IPYR_RALSO;  Q98ER2, IPYR_RHILO;  Q92LH1, IPYR_RHIME;  
Q9RGQ1, IPYR_RHORT;  Q1RIN6, IPYR_RICBR;  Q92H74, IPYR_RICCN;  
Q4UKW0, IPYR_RICFE;  Q9ZCW5, IPYR_RICPR;  Q68WE9, IPYR_RICTY;  
P65749, IPYR_SALTI;  P65748, IPYR_SALTY;  P19117, IPYR_SCHPO;  
Q43187, IPYR_SOLTU;  Q9X8I9, IPYR_STRCO;  P50308, IPYR_SULAC;  
Q97W51, IPYR_SULSO;  Q974Y8, IPYR_SULTO;  P80507, IPYR_SYNY3;  
P37981, IPYR_THEAC;  Q8DHR2, IPYR_THEEB;  Q5JIY3, IPYR_THEKO;  
P77992, IPYR_THELN;  P38576, IPYR_THET8;  Q979E6, IPYR_THEVO;  
Q9PQH6, IPYR_UREPA;  Q9KP34, IPYR_VIBCH;  Q87SW1, IPYR_VIBPA;  
Q8DE89, IPYR_VIBVU;  Q7MPD2, IPYR_VIBVY;  Q8D274, IPYR_WIGBR;  
Q8PH18, IPYR_XANAC;  Q8P5M4, IPYR_XANCP;  P65750, IPYR_XYLFA;  
P65751, IPYR_XYLFT;  Q6C1T4, IPYR_YARLI;  P00817, IPYR_YEAST;  
Q8ZB98, IPYR_YERPE;  Q9C0T9, IPYR_ZYGBA;  Q0VD18, LHPP_BOVIN;  
A5PLK2, LHPP_DANRE;  Q9H008, LHPP_HUMAN;  Q9D7I5, LHPP_MOUSE;  
Q5I0D5, LHPP_RAT;  Q3B8E3, LHPP_XENLA;  Q9X015, MAZG_THEMA;  
O29502, PPAC_ARCFU;  C3PD52, PPAC_BACAA;  C3LG25, PPAC_BACAC;  
Q81PH9, PPAC_BACAN;  B7JRU3, PPAC_BACC0;  Q736P6, PPAC_BACC1;  
B7IJP9, PPAC_BACC2;  C1EXV7, PPAC_BACC3;  B7HA46, PPAC_BACC4;  
B7HUD5, PPAC_BACC7;  A7GQ01, PPAC_BACCN;  B9J353, PPAC_BACCQ;  
Q81CE5, PPAC_BACCR;  Q63AC7, PPAC_BACCZ;  Q6HHR6, PPAC_BACHK;  
Q65E18, PPAC_BACLD;  P56948, PPAC_BACME;  A8FJD5, PPAC_BACP2;  
Q5WDX3, PPAC_BACSK;  P37487, PPAC_BACSU;  A7ZAR2, PPAC_BACVZ;  
A9VIG8, PPAC_BACWK;  C0ZGL2, PPAC_BREBN;  Q97H75, PPAC_CLOAB;  
Q9RRB7, PPAC_DEIRA;  Q834N3, PPAC_ENTFA;  B1YLU2, PPAC_EXIS2;  
C4L0S9, PPAC_EXISA;  Q5FK05, PPAC_LACAC;  Q1GAB5, PPAC_LACDA;  
Q04AP3, PPAC_LACDB;  Q043J4, PPAC_LACGA;  A8YVH1, PPAC_LACH4;  
Q74JD5, PPAC_LACJO;  Q9CEM5, PPAC_LACLA;  Q88W32, PPAC_LACPL;  
Q92BR1, PPAC_LISIN;  C1KV95, PPAC_LISMC;  Q71ZM2, PPAC_LISMF;  
B8DE62, PPAC_LISMH;  Q8Y757, PPAC_LISMO;  A0AIQ0, PPAC_LISW6;  
Q58025, PPAC_METJA;  A0B5R0, PPAC_METTP;  Q8CUT9, PPAC_OCEIH;  
A7X451, PPAC_STAA1;  A6U325, PPAC_STAA2;  Q2FFH6, PPAC_STAA3;  
Q2FWY1, PPAC_STAA8;  A5IU87, PPAC_STAA9;  Q2YU53, PPAC_STAAB;  
Q5HEK1, PPAC_STAAC;  P65752, PPAC_STAAM;  P65753, PPAC_STAAN;  
Q6GFD7, PPAC_STAAR;  Q6G813, PPAC_STAAS;  A8Z2T4, PPAC_STAAT;  
P65754, PPAC_STAAW;  B9DMR8, PPAC_STACT;  Q5HN17, PPAC_STAEQ;  
Q8CNN7, PPAC_STAES;  Q4L7N2, PPAC_STAHJ;  Q49YW3, PPAC_STAS1;  
Q3K0B5, PPAC_STRA1;  Q8E4D4, PPAC_STRA3;  Q8DYS6, PPAC_STRA5;  
C0M7N7, PPAC_STRE4;  B4U4N8, PPAC_STREM;  P95765, PPAC_STRGC;  
O68579, PPAC_STRMU;  P65757, PPAC_STRP1;  Q04JL5, PPAC_STRP2;  
P0DD14, PPAC_STRP3;  B5E699, PPAC_STRP4;  Q5XDN3, PPAC_STRP6;  
C1C8C3, PPAC_STRP7;  P65759, PPAC_STRP8;  A2RG81, PPAC_STRPG;  
B1ICV4, PPAC_STRPI;  B8ZLD4, PPAC_STRPJ;  P65755, PPAC_STRPN;  
P0DD15, PPAC_STRPQ;  B2IR53, PPAC_STRPS;  B5XJY9, PPAC_STRPZ;  
P65756, PPAC_STRR6;  A4W395, PPAC_STRS2;  C0MGI9, PPAC_STRS7;  
A3CPM5, PPAC_STRSV;  A4VWZ2, PPAC_STRSY;  Q5M194, PPAC_STRT1;  
Q5M5T1, PPAC_STRT2;  Q03M65, PPAC_STRTD;  B9DTT7, PPAC_STRU0;  
C1CFB5, PPAC_STRZJ;  C1CLN3, PPAC_STRZP;  C1CSF2, PPAC_STRZT;  
Q9WZ56, PPAC_THEMA;  B7GL49, PPAX_ANOFW;  C3P0C8, PPAX_BACAA;  
C3LED0, PPAX_BACAC;  A0RKU8, PPAX_BACAH;  Q6HQY9, PPAX_BACAN;  
B7JFI8, PPAX_BACC0;  Q72XV8, PPAX_BACC1;  B7IPS5, PPAX_BACC2;  
C1EZE2, PPAX_BACC3;  B7HEG2, PPAX_BACC4;  B7HWY7, PPAX_BACC7;  
B9J4R5, PPAX_BACCQ;  Q815I8, PPAX_BACCR;  Q631J2, PPAX_BACCZ;  
Q9K6Y7, PPAX_BACHD;  Q6HBC8, PPAX_BACHK;  A8FHS1, PPAX_BACP2;  
Q9JMQ2, PPAX_BACSU;  A7Z971, PPAX_BACVZ;  A9VQ75, PPAX_BACWK;  
Q8R821, PPAX_CALS4;  Q8XIY6, PPAX_CLOPE;  Q928B2, PPAX_LISIN;  
C1KYP8, PPAX_LISMC;  Q71WU6, PPAX_LISMF;  B8DBN0, PPAX_LISMH;  
Q8Y4G3, PPAX_LISMO;  A0ALG5, PPAX_LISW6;  Q8ENK3, PPAX_OCEIH;  
Q67YC0, PPSP1_ARATH;  Q9FZ62, PPSP2_ARATH;  Q5E9Y6, PRUN1_BOVIN;  
Q86TP1, PRUN1_HUMAN;  Q8BIW1, PRUN1_MOUSE;  Q6AYG3, PRUN1_RAT;  
Q9C9B9, TTM1_ARATH;  Q9C664, TTM2_ARATH;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-