Accepted Name |
adenosine-5'-diphospho-5'-[DNA] diphosphatase
|
Alternative Name(s) |
5'-App5'-DNA adenylate hydrolase |
aprataxin |
Reaction catalysed |
- a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)
- a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)
|
Comment(s) |
- Aprataxin is a DNA-binding protein involved in different types of DNA
break repair.
- The enzyme acts (among other activities) on abortive DNA ligation
intermediates that contain an adenylate covalently linked to the
5'-phosphate DNA terminus.
- It also acts when the adenylate is covalently linked to the
5'-phosphate of a ribonucleotide linked to a DNA strand, which is the
result of abortive ligase activty on products of EC 3.1.26.4,
an enzyme that cleaves RNA-DNA hybrids on the 5' side of the
ribonucleotide found in the 5'-RNA-DNA-3' junction.
- Aprataxin binds the adenylate group to a histidine residue within the
active site, followed by its hydrolysis from the nucleic acid and
eventual release, leaving a 5'-phosphate terminus that can be
efficiently rejoined.
- The enzyme also possesses the activities of EC 3.6.1.70 and
EC 3.6.1.72.
- Formerly EC 3.1.11.7.
|
Cross-references |
BRENDA | 3.6.1.71 |
EC2PDB | 3.6.1.71 |
ExplorEnz | 3.6.1.71 |
PRIAM enzyme-specific profiles | 3.6.1.71 |
KEGG Ligand Database for Enzyme Nomenclature | 3.6.1.71 |
IUBMB Enzyme Nomenclature | 3.6.1.71 |
IntEnz | 3.6.1.71 |
MEDLINE | Find literature relating to 3.6.1.71 |
MetaCyc | 3.6.1.71 |
Rhea expert-curated reactions | 3.6.1.71 |
UniProtKB/Swiss-Prot |
Q7YRZ2, APTX_BOVIN | P61797, APTX_CANLF | P61798, APTX_CHICK |
P61802, APTX_CIOIN | P61799, APTX_DANRE | Q7Z2E3, APTX_HUMAN |
Q9BGQ0, APTX_MACFA | Q7TQC5, APTX_MOUSE | Q7YRZ1, APTX_PIG |
Q8K4H4, APTX_RAT | O74859, APTX_SCHPO | P61800, APTX_TAKRU |
Q7T287, APTX_XENLA | P61801, APTX_XENTR | Q08702, APTX_YEAST |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
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