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ENZYME

ENZYME entry: EC 3.6.1.72

PURL: https://purl.expasy.org/enzyme/EC/3.6.1.72
Accepted Name
DNA-3'-diphospho-5'-guanosine diphosphatase
Alternative Name(s)
aprataxin
DNA-3'pp5'G guanylate hydrolase
Reaction catalysed
a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)
Comment(s)
  • Aprataxin is a DNA-binding protein that catalyzes (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8).
  • The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release.
  • The enzyme also possesses the activity of EC 3.6.1.71 and EC 3.6.1.72.
  • Formerly EC 3.1.12.2.
Cross-references
BRENDA3.6.1.72
EC2PDB3.6.1.72
ExplorEnz3.6.1.72
KEGG Ligand Database for Enzyme Nomenclature3.6.1.72
IUBMB Enzyme Nomenclature3.6.1.72
MEDLINEFind literature relating to 3.6.1.72
MetaCyc3.6.1.72
Rhea expert-curated reactions3.6.1.72
UniProtKB/Swiss-Prot
Q7YRZ2, APTX_BOVINP61797, APTX_CANLFP61798, APTX_CHICK
P61802, APTX_CIOINP61799, APTX_DANREQ7Z2E3, APTX_HUMAN
Q9BGQ0, APTX_MACFAQ7TQC5, APTX_MOUSEQ7YRZ1, APTX_PIG
Q8K4H4, APTX_RATO74859, APTX_SCHPOP61800, APTX_TAKRU
Q7T287, APTX_XENLAP61801, APTX_XENTRQ08702, APTX_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-