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ENZYME entry: EC 4.1.1.28

Accepted Name
Aromatic-L-amino-acid decarboxylase.
Alternative Name(s)
5-hydroxytryptophan decarboxylase.
Aromatic amino acid decarboxylase.
DOPA decarboxylase.
Hydroxytryptophan decarboxylase.
L-DOPA decarboxylase.
Tryptophan decarboxylase.
Reaction catalysed
  • L-dopa <=> dopamine + CO(2)
  • 5-hydroxy-L-tryptophan <=> 5-hydroxytryptamine + CO(2)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • Also acts on other aromatic L-amino acids, including L-tryptophan.
  • Formerly EC 4.1.1.26 and EC 4.1.1.27.
Cross-references
PROSITEPDOC00329
BRENDA4.1.1.28
EC2PDB4.1.1.28
ExplorEnz4.1.1.28
PRIAM enzyme-specific profiles4.1.1.28
KEGG Ligand Database for Enzyme Nomenclature4.1.1.28
IUBMB Enzyme Nomenclature4.1.1.28
IntEnz4.1.1.28
MEDLINEFind literature relating to 4.1.1.28
MetaCyc4.1.1.28
Rhea expert-curated reactions4.1.1.28
UniProtKB/Swiss-Prot
P27718, DDC_BOVIN;  P34751, DDC_CAEEL;  P22781, DDC_CAVPO;  
O96571, DDC_DROLE;  P05031, DDC_DROME;  O96567, DDC_DROSI;  
P20711, DDC_HUMAN;  P48861, DDC_MANSE;  O88533, DDC_MOUSE;  
P80041, DDC_PIG;  P14173, DDC_RAT;  Q6ZJK7, TDC1_ORYSJ;  
P17770, TDC_CATRO;  P54768, TYDC1_PAPSO;  P54769, TYDC2_PAPSO;  
P54770, TYDC3_PAPSO;  P54771, TYDC5_PAPSO;  

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