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ENZYME entry: EC 4.1.1.77

Accepted Name
2-oxo-3-hexenedioate decarboxylase.
Alternative Name(s)
4-oxalocrotonate carboxy-lyase.
4-oxalocrotonate decarboxylase.
Reaction catalysed
(3E)-2-oxohex-3-enedioate + H(+) <=> 2-oxopent-4-enoate + CO2
Comment(s)
  • Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols.
  • The enzyme has been reported to accept multiple tautomeric forms.
  • However, careful analysis of the stability of the different tautomers, as well as characterization of the enzyme that produces its substrate, EC 5.3.2.6, showed that the actual substrate for the enzyme is (3E)-2-oxohex-3-enedioate.
Cross-references
BRENDA4.1.1.77
EC2PDB4.1.1.77
ExplorEnz4.1.1.77
PRIAM enzyme-specific profiles4.1.1.77
KEGG Ligand Database for Enzyme Nomenclature4.1.1.77
IUBMB Enzyme Nomenclature4.1.1.77
IntEnz4.1.1.77
MEDLINEFind literature relating to 4.1.1.77
MetaCyc4.1.1.77
Rhea expert-curated reactions4.1.1.77
UniProtKB/Swiss-Prot
Q9KWS3, AMNE_PSESP;  P49156, DMPH_PSEUF;  P49155, XYLI_PSEPU;  

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