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ENZYME entry: EC 4.1.1.83

Accepted Name
4-hydroxyphenylacetate decarboxylase.
Alternative Name(s)
4-Hpd.
4-hydroxyphenylacetate carboxy-lyase.
p-Hpd.
p-hydroxyphenylacetate decarboxylase.
Reaction catalysed
(4-hydroxyphenyl)acetate <=> 4-methylphenol + CO(2)
Comment(s)
  • The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product.
  • The enzyme is a glycyl radical enzyme.
Cross-references
BRENDA4.1.1.83
EC2PDB4.1.1.83
ExplorEnz4.1.1.83
PRIAM enzyme-specific profiles4.1.1.83
KEGG Ligand Database for Enzyme Nomenclature4.1.1.83
IUBMB Enzyme Nomenclature4.1.1.83
IntEnz4.1.1.83
MEDLINEFind literature relating to 4.1.1.83
MetaCyc4.1.1.83
Rhea expert-curated reactions4.1.1.83
UniProtKB/Swiss-Prot
Q18CP5, HPDL_CLOD6;  C9XIS5, HPDL_CLODC;  Q84F16, HPDL_CLODI;  
C9YHW1, HPDL_CLODR;  Q38HX4, HPDL_CLOSL;  Q18CP4, HPDS_CLOD6;  
C9XIS6, HPDS_CLODC;  Q84F15, HPDS_CLODI;  C9YHW2, HPDS_CLODR;  
Q38HX3, HPDS_CLOSL;  

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