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ENZYME entry: EC 4.1.2.46

Accepted Name
Aliphatic (R)-hydroxynitrile lyase.
Alternative Name(s)
(R)-hydroxynitrile lyase.
(R)-oxynitrilase.
Reaction catalysed
(2R)-2-hydroxy-2-methylbutanenitrile <=> cyanide + butan-2-one
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme catalyzes the stereoselective synthesis of aliphatic (R)- cyanohydrins.
  • No activity toward mandelonitrile and 4-hydroxymandelonitrile.
  • Natural substrates for the (R)-oxynitrilase from Linum usitatissimum are acetone and butan-2-one, which are the building blocks of the cyanogen glycosides in Linum, linamarin and lotaustralin, or linustatin and neolinustatin, respectively.
  • Formerly EC 4.1.2.37 and EC 4.1.2.39.
Cross-references
BRENDA4.1.2.46
EC2PDB4.1.2.46
ExplorEnz4.1.2.46
PRIAM enzyme-specific profiles4.1.2.46
KEGG Ligand Database for Enzyme Nomenclature4.1.2.46
IUBMB Enzyme Nomenclature4.1.2.46
IntEnz4.1.2.46
MEDLINEFind literature relating to 4.1.2.46
MetaCyc4.1.2.46
UniProtKB/Swiss-Prot
P93243, AHNL_LINUS

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