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ENZYME entry: EC

Accepted Name
(S)-hydroxynitrile lyase.
Alternative Name(s)
(S)-cyanohydrin producing hydroxynitrile lyase.
hydroxynitrile lyase.
Reaction catalysed
  • a monosubstituted aliphatic (S)-hydroxynitrile <=> an aldehyde + hydrogen cyanide
  • a disubstituted aliphatic (S)-hydroxynitrile <=> a ketone + hydrogen cyanide
  • an aromatic (S)-hydroxynitrile <=> an aromatic aldehyde + hydrogen cyanide
  • Hydroxynitrile lyases catalyzes the the cleavage of hydroxynitriles into cyanide and the corresponding aldehyde or ketone.
  • In nature the liberation of cyanide serves as a defense mechanism against herbivores and microbial attack in plants.
  • In vitro the enzymes from Manihot esculenta and Hevea brasiliensis accept a broad range of aliphatic and aromatic carbonyl compounds as substrates and catalyze the formation of (S)-hydroxynitriles.
  • Formerly EC and EC
PRIAM enzyme-specific profiles4.1.2.47
KEGG Ligand Database for Enzyme Nomenclature4.1.2.47
IUBMB Enzyme Nomenclature4.1.2.47
MEDLINEFind literature relating to
Rhea expert-curated reactions4.1.2.47
P52704, HNL_HEVBR;  P52705, HNL_MANES;  

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