A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.2.50
Accepted Name |
6-carboxytetrahydropterin synthase.
|
Alternative Name(s) |
CPH4 synthase. |
Reaction catalysed |
7,8-dihydroneopterin 3'-triphosphate + H(2)O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate |
Cofactor(s) |
Zn(2+).
|
Comment(s) |
- Isolated from the bacteria Bacillus subtilis and Escherichia coli.
- The reaction is part of the biosynthesis pathway of queuosine.
- The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-
tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-
tetrahydropterin.
|
Cross-references |
BRENDA | 4.1.2.50 |
EC2PDB | 4.1.2.50 |
ExplorEnz | 4.1.2.50 |
PRIAM enzyme-specific profiles | 4.1.2.50 |
KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.50 |
IUBMB Enzyme Nomenclature | 4.1.2.50 |
IntEnz | 4.1.2.50 |
MEDLINE | Find literature relating to 4.1.2.50 |
MetaCyc | 4.1.2.50 |
UniProtKB/Swiss-Prot |
O66626, QUED_AQUAE; | O29809, QUED_ARCFU; | O31676, QUED_BACSU; |
Q8K9D8, QUED_BUCAP; | P65871, QUED_ECO57; | P65870, QUED_ECOLI; |
P44123, QUED_HAEIN; | B0R9W7, QUED_HALS3; | Q9ZKR8, QUED_HELPJ; |
O25587, QUED_HELPY; | Q58668, QUED_METJA; | O27296, QUED_METTH; |
Q9UXZ4, QUED_PYRAB; | O59602, QUED_PYRHO; | Q1RHI6, QUED_RICBR; |
Q92J44, QUED_RICCN; | Q4UKI6, QUED_RICFE; | Q9ZDY5, QUED_RICPR; |
Q68XI9, QUED_RICTY; | P65872, QUED_SHIFL; | Q55798, QUED_SYNY3; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-