A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.2.50
| Accepted Name |
|---|
| 6-carboxytetrahydropterin synthase.
|
| Alternative Name(s) |
|---|
| CPH4 synthase. |
| Reaction catalysed |
|---|
| 7,8-dihydroneopterin 3'-triphosphate + H(2)O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate |
| Cofactor(s) |
|---|
| Zn(2+).
|
| Comment(s) |
|---|
- Isolated from the bacteria Bacillus subtilis and Escherichia coli.
- The reaction is part of the biosynthesis pathway of queuosine.
- The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-
tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-
tetrahydropterin.
|
| Cross-references |
|---|
| BRENDA | 4.1.2.50 |
| EC2PDB | 4.1.2.50 |
| ExplorEnz | 4.1.2.50 |
| PRIAM enzyme-specific profiles | 4.1.2.50 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.50 |
| IUBMB Enzyme Nomenclature | 4.1.2.50 |
| IntEnz | 4.1.2.50 |
| MEDLINE | Find literature relating to 4.1.2.50 |
| MetaCyc | 4.1.2.50 |
| UniProtKB/Swiss-Prot |
| O66626, QUED_AQUAE; | O29809, QUED_ARCFU; | O31676, QUED_BACSU; |
| Q8K9D8, QUED_BUCAP; | P65871, QUED_ECO57; | P65870, QUED_ECOLI; |
| P44123, QUED_HAEIN; | B0R9W7, QUED_HALS3; | Q9ZKR8, QUED_HELPJ; |
| O25587, QUED_HELPY; | Q58668, QUED_METJA; | O27296, QUED_METTH; |
| Q9UXZ4, QUED_PYRAB; | O59602, QUED_PYRHO; | Q1RHI6, QUED_RICBR; |
| Q92J44, QUED_RICCN; | Q4UKI6, QUED_RICFE; | Q9ZDY5, QUED_RICPR; |
| Q68XI9, QUED_RICTY; | P65872, QUED_SHIFL; | Q55798, QUED_SYNY3; |
|
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