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ENZYME entry: EC 4.1.2.50

Accepted Name
6-carboxytetrahydropterin synthase.
Alternative Name(s)
CPH4 synthase.
Reaction catalysed
7,8-dihydroneopterin 3'-triphosphate + H(2)O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate
Cofactor(s)
Zn(2+).
Comment(s)
  • Isolated from the bacteria Bacillus subtilis and Escherichia coli.
  • The reaction is part of the biosynthesis pathway of queuosine.
  • The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8- tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8- tetrahydropterin.
Cross-references
BRENDA4.1.2.50
EC2PDB4.1.2.50
ExplorEnz4.1.2.50
PRIAM enzyme-specific profiles4.1.2.50
KEGG Ligand Database for Enzyme Nomenclature4.1.2.50
IUBMB Enzyme Nomenclature4.1.2.50
IntEnz4.1.2.50
MEDLINEFind literature relating to 4.1.2.50
MetaCyc4.1.2.50
UniProtKB/Swiss-Prot
O66626, QUED_AQUAE;  O29809, QUED_ARCFU;  O31676, QUED_BACSU;  
Q8K9D8, QUED_BUCAP;  P65871, QUED_ECO57;  P65870, QUED_ECOLI;  
P44123, QUED_HAEIN;  B0R9W7, QUED_HALS3;  Q9ZKR8, QUED_HELPJ;  
O25587, QUED_HELPY;  Q58668, QUED_METJA;  O27296, QUED_METTH;  
Q9UXZ4, QUED_PYRAB;  O59602, QUED_PYRHO;  Q1RHI6, QUED_RICBR;  
Q92J44, QUED_RICCN;  Q4UKI6, QUED_RICFE;  Q9ZDY5, QUED_RICPR;  
Q68XI9, QUED_RICTY;  P65872, QUED_SHIFL;  Q55798, QUED_SYNY3;  

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