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ENZYME

ENZYME entry: EC 4.1.2.52

PURL: https://purl.expasy.org/enzyme/EC/4.1.2.52
Accepted Name
4-hydroxy-2-oxoheptanedioate aldolase
Alternative Name(s)
2,4-dihydroxyhept-2-enedioate aldolase
4-hydroxy-2-ketoheptanedioate aldolase
HHED aldolase
HKHD aldolase
Reaction catalysed
4-hydroxy-2-oxoheptanedioate = succinate semialdehyde + pyruvate
Comment(s)
  • The enzyme is also able to catalyze the aldol cleavage of 4-hydroxy- 2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency.
  • In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate.
  • The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate.
  • Formerly EC 4.1.2.n4.
Cross-references
BRENDA4.1.2.52
EC2PDB4.1.2.52
ExplorEnz4.1.2.52
KEGG Ligand Database for Enzyme Nomenclature4.1.2.52
IUBMB Enzyme Nomenclature4.1.2.52
MEDLINEFind literature relating to 4.1.2.52
MetaCyc4.1.2.52
Rhea expert-curated reactions4.1.2.52
UniProtKB/Swiss-Prot
A8A876, HPCH_ECOHSB1IS70, HPCH_ECOLCQ47098, HPCH_ECOLX
B6I2N1, HPCH_ECOSEA6THU5, HPCH_KLEP7B5Y2D2, HPCH_KLEV3
B5F1Y9, HPCH_SALA4A9MH59, HPCH_SALARQ57QP9, HPCH_SALCH
B5FR34, HPCH_SALDCQ9RPV0, HPCH_SALDUB5R043, HPCH_SALEP
B5R6F7, HPCH_SALG2B4TEM9, HPCH_SALHSB4T2T9, HPCH_SALNS
Q5PG96, HPCH_SALPAA9N6T0, HPCH_SALPBC0Q8A0, HPCH_SALPC
B5BBH8, HPCH_SALPKB4TSL7, HPCH_SALSVQ8Z7P9, HPCH_SALTI
Q8ZQ47, HPCH_SALTYB2TZN1, HPCH_SHIB3Q31SY8, HPCH_SHIBS
Q83P19, HPCH_SHIFLQ3YU43, HPCH_SHISS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-