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ENZYME entry: EC 4.1.2.61

Accepted Name
Feruloyl-CoA hydratase/lyase.
Reaction catalysed
Feruloyl-CoA + H(2)O <=> vanillin + acetyl-CoA
Comment(s)
  • The enzyme is a member of the enoyl-CoA hydratase/isomerase superfamily.
  • It catalyzes a two-step process involving first the hydration of the double bond of feruloyl-CoA and then the cleavage of the resultant beta-hydroxy thioester by retro-aldol reaction.
  • (E)-caffeoyl-CoA and (E)-4-coumaroyl-CoA are also substrates.
  • Formerly EC 4.1.2.41 and EC 4.2.1.101.
Cross-references
BRENDA4.1.2.61
EC2PDB4.1.2.61
ExplorEnz4.1.2.61
PRIAM enzyme-specific profiles4.1.2.61
KEGG Ligand Database for Enzyme Nomenclature4.1.2.61
IUBMB Enzyme Nomenclature4.1.2.61
IntEnz4.1.2.61
MEDLINEFind literature relating to 4.1.2.61
MetaCyc4.1.2.61
Rhea expert-curated reactions4.1.2.61
UniProtKB/Swiss-Prot
O69762, HCHL_PSEFL

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