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ENZYME entry: EC 4.1.2.62

Accepted Name
5-deoxyribulose 1-phosphate aldolase.
Alternative Name(s)
5-(methylthio)ribulose-1-phosphate aldolase.
Reaction catalysed
  • 5-deoxy-D-ribulose 1-phosphate <=> glycerone phosphate + acetaldehyde
  • S-methyl-5-thio-D-ribulose 1-phosphate <=> glycerone phosphate + (2-methylsulfanyl)acetaldehyde
Comment(s)
  • The enzyme, originally characterized from the bacterium Rhodospirillum rubrum, is involved in degradation pathways for 5'-deoxyadenosine and S-methyl-5'-thioadenosine, which are formed from S-adenosyl-L-methionine (SAM, AdoMet) by radical SAM enzymes and other types of SAM-dependent enzymes, respectively.
  • The enzyme requires a divalent metal cation, with Co(2+) producing the highest activity.
Cross-references
BRENDA4.1.2.62
EC2PDB4.1.2.62
ExplorEnz4.1.2.62
PRIAM enzyme-specific profiles4.1.2.62
KEGG Ligand Database for Enzyme Nomenclature4.1.2.62
IUBMB Enzyme Nomenclature4.1.2.62
IntEnz4.1.2.62
MEDLINEFind literature relating to 4.1.2.62
MetaCyc4.1.2.62
Rhea expert-curated reactions4.1.2.62
UniProtKB/Swiss-Prot
B7MMH7, ALD2_ECO45;  Q2RXI1, ALD2_RHORT;  

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