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ENZYME entry: EC 4.1.2.63

Accepted Name
2-hydroxyacyl-CoA lyase.
Alternative Name(s)
2-HPCL.
2-hydroxyphytanoyl-CoA lyase.
Reaction catalysed
  • a 2-hydroxy-3-methyl fatty acyl-CoA <=> a 2-methyl-branched fatty aldehyde + formyl-CoA
  • an (R)-2-hydroxy-long-chain-fatty acyl-CoA <=> a long-chain fatty aldehyde + formyl-CoA
Comment(s)
  • This peroxisomal enzyme, found in animals, is involved in the alpha- oxidation of 3-methyl-branched fatty acids like phytanic acid and the shortening of 2-hydroxy long-chain fatty acids.
  • Formerly EC 4.1.2.n2.
Cross-references
BRENDA4.1.2.63
EC2PDB4.1.2.63
ExplorEnz4.1.2.63
PRIAM enzyme-specific profiles4.1.2.63
KEGG Ligand Database for Enzyme Nomenclature4.1.2.63
IUBMB Enzyme Nomenclature4.1.2.63
IntEnz4.1.2.63
MEDLINEFind literature relating to 4.1.2.63
MetaCyc4.1.2.63
Rhea expert-curated reactions4.1.2.63
UniProtKB/Swiss-Prot
Q54DA9, HACL1_DICDI;  Q9UJ83, HACL1_HUMAN;  Q9QXE0, HACL1_MOUSE;  
Q8CHM7, HACL1_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-