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ENZYME entry: EC 4.1.3.16

Accepted Name
4-hydroxy-2-oxoglutarate aldolase.
Alternative Name(s)
2-keto-4-hydroxyglutarate aldolase.
2-oxo-4-hydroxyglutarate aldolase.
4-hydroxy-2-oxoglutarate glyoxylate-lyase.
KHG-aldolase.
KHGA.
Reaction catalysed
  • (4R)-4-hydroxy-2-oxoglutarate <=> pyruvate + glyoxylate
  • (4S)-4-hydroxy-2-oxoglutarate <=> pyruvate + glyoxylate
Comment(s)
  • The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate.
  • Formerly EC 4.1.2.1 and EC 4.1.2.31.
Cross-references
PROSITEPDOC00144
BRENDA4.1.3.16
EC2PDB4.1.3.16
ExplorEnz4.1.3.16
PRIAM enzyme-specific profiles4.1.3.16
KEGG Ligand Database for Enzyme Nomenclature4.1.3.16
IUBMB Enzyme Nomenclature4.1.3.16
IntEnz4.1.3.16
MEDLINEFind literature relating to 4.1.3.16
MetaCyc4.1.3.16
Rhea expert-curated reactions4.1.3.16
UniProtKB/Swiss-Prot
P50846, ALKH_BACSU;  P38448, ALKH_DICD3;  P0A957, ALKH_ECO57;  
P0A956, ALKH_ECOL6;  P0A955, ALKH_ECOLI;  P44480, ALKH_HAEIN;  
P0A958, ALKH_SHIFL;  O83578, ALKH_TREPA;  Q00384, ALKH_ZYMMO;  
Q9AQI0, HMGA_PSEOC;  Q0P5I5, HOGA1_BOVIN;  P0CL20, HOGA1_COCIM;  
Q6NY77, HOGA1_DANRE;  Q5BD77, HOGA1_EMENI;  Q86XE5, HOGA1_HUMAN;  
Q9DCU9, HOGA1_MOUSE;  Q5XGL6, HOGA1_XENLA;  Q5M8W9, HOGA1_XENTR;  

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