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ENZYME

ENZYME entry: EC 4.1.3.17

Accepted Name
4-hydroxy-4-methyl-2-oxoglutarate aldolase
Alternative Name(s)
4-carboxy-4-hydroxy-2-oxoadipate aldolase
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase
CHA aldolase
HMG aldolase
Reaction catalysed
  • 4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate
  • 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate
Comment(s)
  • This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate.
  • The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2- oxoglutarate to glyoxylate and pyruvate, and also catalyzes the reaction of EC 4.1.1.3.
Cross-references
BRENDA4.1.3.17
EC2PDB4.1.3.17
ExplorEnz4.1.3.17
PRIAM enzyme-specific profiles4.1.3.17
KEGG Ligand Database for Enzyme Nomenclature4.1.3.17
IUBMB Enzyme Nomenclature4.1.3.17
IntEnz4.1.3.17
MEDLINEFind literature relating to 4.1.3.17
MetaCyc4.1.3.17
Rhea expert-curated reactions4.1.3.17
UniProtKB/Swiss-Prot
Q2HBN5, CGHB_CHAGBQ88JX9, GALC_PSEPKQ9AQI0, HMGA_PSEOC
A5W059, HMGA_PSEP1G2IQQ8, LIGK_SPHSKQ9M8R9, RRAA1_ARATH
Q9FFE0, RRAA2_ARATHQ9FH13, RRAA3_ARATHQ6FCF4, RRAAH_ACIAD
Q21X23, RRAAH_ALBFTQ0VQ55, RRAAH_ALCBSQ0A9G6, RRAAH_ALKEH
Q5P203, RRAAH_AROAEC1DHC2, RRAAH_AZOVDQ81N49, RRAAH_BACAN
Q734S7, RRAAH_BACC1Q638R8, RRAAH_BACCZA9AHQ6, RRAAH_BURM1
A3MKY3, RRAAH_BURM7A2SB35, RRAAH_BURM9Q62J86, RRAAH_BURMA
A1V5A8, RRAAH_BURMSA3NWR9, RRAAH_BURP0Q3JQZ3, RRAAH_BURP1
A3NAY8, RRAAH_BURP6Q63SX7, RRAAH_BURPSQ2SX33, RRAAH_BURTA
Q7NXI6, RRAAH_CHRVOQ8FQY0, RRAAH_COREFQ8NRW6, RRAAH_CORGL
Q4JVU3, RRAAH_CORJKQ0K9J4, RRAAH_CUPNHQ46ZV6, RRAAH_CUPPJ
B3R2J3, RRAAH_CUPTRQ47BF5, RRAAH_DECARQ9RW10, RRAAH_DEIRA
Q2SK70, RRAAH_HAHCHQ9KBI9, RRAAH_HALH5A1WU91, RRAAH_HALHL
C1D7M1, RRAAH_LARHHA6VX14, RRAAH_MARMSQ607E7, RRAAH_METCA
A0Q981, RRAAH_MYCA1P0A667, RRAAH_MYCBOA1KQI8, RRAAH_MYCBP
C1AIV9, RRAAH_MYCBTA4T3Z0, RRAAH_MYCGIB8ZTT3, RRAAH_MYCLB
Q9CDD2, RRAAH_MYCLEQ745I2, RRAAH_MYCPAA0R664, RRAAH_MYCS2
A3Q7S1, RRAAH_MYCSJA1UNC5, RRAAH_MYCSKQ1B1S4, RRAAH_MYCSS
A5U9I2, RRAAH_MYCTAP9WGY2, RRAAH_MYCTOP9WGY3, RRAAH_MYCTU
A1TGZ7, RRAAH_MYCVPQ5Z3P5, RRAAH_NOCFAB2JIG2, RRAAH_PARP8
B2SXN2, RRAAH_PARPJQ13X79, RRAAH_PARXLQ6LUQ3, RRAAH_PHOPR
Q48JZ3, RRAAH_PSE14A6V753, RRAAH_PSEA7B7VBA7, RRAAH_PSEA8
Q02KR3, RRAAH_PSEABQ9I2W7, RRAAH_PSEAEQ1ICM4, RRAAH_PSEE4
Q4KFJ3, RRAAH_PSEF5Q9S4U0, RRAAH_PSEFLC3K0T6, RRAAH_PSEFS
A4XU32, RRAAH_PSEMYA5W6M0, RRAAH_PSEP1Q3KFE1, RRAAH_PSEPF
B0KG79, RRAAH_PSEPGQ88L51, RRAAH_PSEPKB1J596, RRAAH_PSEPW
Q883Q6, RRAAH_PSESMQ4ZUN7, RRAAH_PSEU2Q8XZP1, RRAAH_RALSO
B6IPN3, RRAAH_RHOCSA4FBN0, RRAAH_SACENQ8EE23, RRAAH_SHEON
A4VL60, RRAAH_STUS1Q72J23, RRAAH_THET2Q5SIP7, RRAAH_THET8
B8GM40, RRAAH_THISHQ9KPK1, RRAAH_VIBCHQ87SD2, RRAAH_VIBPA
Q8DEP0, RRAAH_VIBVUQ7MNR7, RRAAH_VIBVYQ8PIT8, RRAAH_XANAC
Q3BRB4, RRAAH_XANC5Q4UWM5, RRAAH_XANC8B0RQZ0, RRAAH_XANCB
Q8P7H4, RRAAH_XANCPQ2P5H9, RRAAH_XANOMB2SSI8, RRAAH_XANOP
P40011, RRAAH_YEASTA0A0F7GG11, TASA_HAPIR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-