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ENZYME entry: EC 4.1.3.17

Accepted Name
4-hydroxy-4-methyl-2-oxoglutarate aldolase.
Alternative Name(s)
4-carboxy-4-hydroxy-2-oxoadipate aldolase.
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase.
CHA aldolase.
HMG aldolase.
Reaction catalysed
  • 4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate
  • 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate
Cofactor(s)
Divalent cation.
Comment(s)
  • This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate.
  • The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2- oxoglutarate to glyoxylate and pyruvate, and also catalyzes the reaction of EC 4.1.1.3.
Cross-references
BRENDA4.1.3.17
EC2PDB4.1.3.17
ExplorEnz4.1.3.17
PRIAM enzyme-specific profiles4.1.3.17
KEGG Ligand Database for Enzyme Nomenclature4.1.3.17
IUBMB Enzyme Nomenclature4.1.3.17
IntEnz4.1.3.17
MEDLINEFind literature relating to 4.1.3.17
MetaCyc4.1.3.17
Rhea expert-curated reactions4.1.3.17
UniProtKB/Swiss-Prot
Q2HBN5, CGHB_CHAGB;  Q88JX9, GALC_PSEPK;  Q9AQI0, HMGA_PSEOC;  
A5W059, HMGA_PSEP1;  G2IQQ8, LIGK_SPHSK;  Q9M8R9, RRAA1_ARATH;  
Q9FFE0, RRAA2_ARATH;  Q9FH13, RRAA3_ARATH;  Q6FCF4, RRAAH_ACIAD;  
Q0VQ55, RRAAH_ALCBS;  Q0A9G6, RRAAH_ALKEH;  Q9KBI9, RRAAH_ALKHC;  
Q5P203, RRAAH_AROAE;  C1DHC2, RRAAH_AZOVD;  Q81N49, RRAAH_BACAN;  
Q734S7, RRAAH_BACC1;  Q638R8, RRAAH_BACCZ;  A9AHQ6, RRAAH_BURM1;  
A3MKY3, RRAAH_BURM7;  A2SB35, RRAAH_BURM9;  Q62J86, RRAAH_BURMA;  
A1V5A8, RRAAH_BURMS;  A3NWR9, RRAAH_BURP0;  Q3JQZ3, RRAAH_BURP1;  
A3NAY8, RRAAH_BURP6;  Q63SX7, RRAAH_BURPS;  Q2SX33, RRAAH_BURTA;  
Q7NXI6, RRAAH_CHRVO;  Q8FQY0, RRAAH_COREF;  Q8NRW6, RRAAH_CORGL;  
Q4JVU3, RRAAH_CORJK;  Q0K9J4, RRAAH_CUPNH;  Q46ZV6, RRAAH_CUPPJ;  
B3R2J3, RRAAH_CUPTR;  Q47BF5, RRAAH_DECAR;  Q9RW10, RRAAH_DEIRA;  
Q2SK70, RRAAH_HAHCH;  A1WU91, RRAAH_HALHL;  C1D7M1, RRAAH_LARHH;  
A6VX14, RRAAH_MARMS;  Q607E7, RRAAH_METCA;  A0Q981, RRAAH_MYCA1;  
P0A667, RRAAH_MYCBO;  A1KQI8, RRAAH_MYCBP;  C1AIV9, RRAAH_MYCBT;  
A4T3Z0, RRAAH_MYCGI;  B8ZTT3, RRAAH_MYCLB;  Q9CDD2, RRAAH_MYCLE;  
Q745I2, RRAAH_MYCPA;  A0R664, RRAAH_MYCS2;  A3Q7S1, RRAAH_MYCSJ;  
A1UNC5, RRAAH_MYCSK;  Q1B1S4, RRAAH_MYCSS;  A5U9I2, RRAAH_MYCTA;  
P9WGY2, RRAAH_MYCTO;  P9WGY3, RRAAH_MYCTU;  A1TGZ7, RRAAH_MYCVP;  
Q5Z3P5, RRAAH_NOCFA;  B2JIG2, RRAAH_PARP8;  B2SXN2, RRAAH_PARPJ;  
Q13X79, RRAAH_PARXL;  Q6LUQ3, RRAAH_PHOPR;  Q48JZ3, RRAAH_PSE14;  
A6V753, RRAAH_PSEA7;  B7VBA7, RRAAH_PSEA8;  Q02KR3, RRAAH_PSEAB;  
Q9I2W7, RRAAH_PSEAE;  Q1ICM4, RRAAH_PSEE4;  Q4KFJ3, RRAAH_PSEF5;  
Q9S4U0, RRAAH_PSEFL;  C3K0T6, RRAAH_PSEFS;  A4XU32, RRAAH_PSEMY;  
A5W6M0, RRAAH_PSEP1;  Q3KFE1, RRAAH_PSEPF;  B0KG79, RRAAH_PSEPG;  
Q88L51, RRAAH_PSEPK;  B1J596, RRAAH_PSEPW;  Q883Q6, RRAAH_PSESM;  
Q4ZUN7, RRAAH_PSEU2;  A4VL60, RRAAH_PSEU5;  Q8XZP1, RRAAH_RALSO;  
B6IPN3, RRAAH_RHOCS;  Q21X23, RRAAH_RHOFT;  A4FBN0, RRAAH_SACEN;  
Q8EE23, RRAAH_SHEON;  Q72J23, RRAAH_THET2;  Q5SIP7, RRAAH_THET8;  
B8GM40, RRAAH_THISH;  Q9KPK1, RRAAH_VIBCH;  Q87SD2, RRAAH_VIBPA;  
Q8DEP0, RRAAH_VIBVU;  Q7MNR7, RRAAH_VIBVY;  Q8PIT8, RRAAH_XANAC;  
Q3BRB4, RRAAH_XANC5;  Q4UWM5, RRAAH_XANC8;  B0RQZ0, RRAAH_XANCB;  
Q8P7H4, RRAAH_XANCP;  Q2P5H9, RRAAH_XANOM;  B2SSI8, RRAAH_XANOP;  
P40011, RRAAH_YEAST;  A0A0F7GG11, TASA_HAPIR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.3.-
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