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ENZYME entry: EC 4.1.3.41

Accepted Name
3-hydroxy-D-aspartate aldolase.
Alternative Name(s)
D-3-hydroxyaspartate aldolase.
Reaction catalysed
  • Threo-3-hydroxy-D-aspartate <=> glycine + glyoxylate
  • D-erythro-3-hydroxyaspartate <=> glycine + glyoxylate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme, purified from the bacterium Paracoccus denitrificansy IFO 13301, is strictly D-specific as to the alpha-position of the substrate, but accepts both the threo and erythro forms at the beta- position.
  • The erythro form is a far better substrate (about 100 fold).
  • The enzyme can also accept D-allothreonine, D-threonine, erythro-3- phenyl-D-serine and threo-3-phenyl-D-serine.
  • Different from EC 4.1.3.14.
  • Requires a divalent cation, such as Mg(2+), Mn(2+) or Co(2+).
Cross-references
BRENDA4.1.3.41
EC2PDB4.1.3.41
ExplorEnz4.1.3.41
PRIAM enzyme-specific profiles4.1.3.41
KEGG Ligand Database for Enzyme Nomenclature4.1.3.41
IUBMB Enzyme Nomenclature4.1.3.41
IntEnz4.1.3.41
MEDLINEFind literature relating to 4.1.3.41
MetaCyc4.1.3.41
Rhea expert-curated reactions4.1.3.41
UniProtKB/Swiss-Prot
Q8GRC8, BHCC_PARDE;  A1B8Z1, BHCC_PARDP;  

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