ENZYME entry: EC 4.1.3.41
Accepted Name |
3-hydroxy-D-aspartate aldolase.
|
Alternative Name(s) |
D-3-hydroxyaspartate aldolase. |
Reaction catalysed |
- Threo-3-hydroxy-D-aspartate <=> glycine + glyoxylate
- D-erythro-3-hydroxyaspartate <=> glycine + glyoxylate
|
Cofactor(s) |
Pyridoxal 5'-phosphate.
|
Comment(s) |
- The enzyme, purified from the bacterium Paracoccus denitrificansy IFO
13301, is strictly D-specific as to the alpha-position of the
substrate, but accepts both the threo and erythro forms at the beta-
position.
- The erythro form is a far better substrate (about 100 fold).
- The enzyme can also accept D-allothreonine, D-threonine, erythro-3-
phenyl-D-serine and threo-3-phenyl-D-serine.
- Different from EC 4.1.3.14.
- Requires a divalent cation, such as Mg(2+), Mn(2+) or Co(2+).
|
Cross-references |
BRENDA | 4.1.3.41 |
EC2PDB | 4.1.3.41 |
ExplorEnz | 4.1.3.41 |
PRIAM enzyme-specific profiles | 4.1.3.41 |
KEGG Ligand Database for Enzyme Nomenclature | 4.1.3.41 |
IUBMB Enzyme Nomenclature | 4.1.3.41 |
IntEnz | 4.1.3.41 |
MEDLINE | Find literature relating to 4.1.3.41 |
MetaCyc | 4.1.3.41 |
Rhea expert-curated reactions | 4.1.3.41 |
UniProtKB/Swiss-Prot |
|
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