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ENZYME entry: EC 4.1.3.44

Accepted Name
tRNA 4-demethylwyosine synthase (AdoMet-dependent)
Reaction catalysed
N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine <=> 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine
Comment(s)
  • This enzyme, which is a member of the superfamily of S-adenosyl-L- methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters.
  • Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine.
  • The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine.
Cross-references
BRENDA4.1.3.44
EC2PDB4.1.3.44
ExplorEnz4.1.3.44
PRIAM enzyme-specific profiles4.1.3.44
KEGG Ligand Database for Enzyme Nomenclature4.1.3.44
IUBMB Enzyme Nomenclature4.1.3.44
IntEnz4.1.3.44
MEDLINEFind literature relating to 4.1.3.44
MetaCyc4.1.3.44
Rhea expert-curated reactions4.1.3.44
UniProtKB/Swiss-Prot
Q6NUM6, TYW1B_HUMANQ8RXN5, TYW1_ARATHQ08C92, TYW1_DANRE
Q9NV66, TYW1_HUMANQ57705, TYW1_METJAQ8BJM7, TYW1_MOUSE
Q8H8N3, TYW1_ORYSJQ5REF9, TYW1_PONABQ9V1F9, TYW1_PYRAB
O59412, TYW1_PYRHOO59761, TYW1_SCHPOQ2KHP8, TYW1_XENLA
Q08960, TYW1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-