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ENZYME entry: EC 4.1.99.12

Accepted Name
3,4-dihydroxy-2-butanone-4-phosphate synthase.
Alternative Name(s)
DHBP synthase.
L-3,4-dihydroxybutan-2-one-4-phosphate synthase.
Reaction catalysed
D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)
Comment(s)
  • The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5.
  • The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
Cross-references
BRENDA4.1.99.12
EC2PDB4.1.99.12
ExplorEnz4.1.99.12
PRIAM enzyme-specific profiles4.1.99.12
KEGG Ligand Database for Enzyme Nomenclature4.1.99.12
IUBMB Enzyme Nomenclature4.1.99.12
IntEnz4.1.99.12
MEDLINEFind literature relating to 4.1.99.12
MetaCyc4.1.99.12
Rhea expert-curated reactions4.1.99.12
UniProtKB/Swiss-Prot
Q5A3V6, RIB3_CANAL;  Q8TG90, RIB3_MAGO7;  O60181, RIB3_SCHPO;  
Q99258, RIB3_YEAST;  P47924, RIBA1_ARATH;  Q6Z234, RIBA1_ORYSJ;  
Q6NLQ7, RIBA2_ARATH;  Q0E079, RIBA2_ORYSJ;  A3MZA2, RIBBA_ACTP2;  
B3H0P8, RIBBA_ACTP7;  B0BTN8, RIBBA_ACTPJ;  P50855, RIBBA_ACTPL;  
Q5WH08, RIBBA_ALKCK;  O66679, RIBBA_AQUAE;  C3P7P7, RIBBA_BACAA;  
C3LIX7, RIBBA_BACAC;  A0RIB3, RIBBA_BACAH;  P51695, RIBBA_BACAM;  
Q81MB6, RIBBA_BACAN;  B7JLW6, RIBBA_BACC0;  Q731I5, RIBBA_BACC1;  
B7IWM5, RIBBA_BACC2;  C1EQY5, RIBBA_BACC3;  B7HAY4, RIBBA_BACC4;  
B7HNM8, RIBBA_BACC7;  A7GSD5, RIBBA_BACCN;  B9IWX4, RIBBA_BACCQ;  
Q818X6, RIBBA_BACCR;  Q635H0, RIBBA_BACCZ;  Q5LHT1, RIBBA_BACFN;  
Q64YT3, RIBBA_BACFR;  Q6HE54, RIBBA_BACHK;  A9VG50, RIBBA_BACMK;  
P17620, RIBBA_BACSU;  Q8A528, RIBBA_BACTN;  A7Z675, RIBBA_BACVZ;  
C0ZKW2, RIBBA_BREBN;  Q3B2I6, RIBBA_CHLL3;  Q9PLJ5, RIBBA_CHLMU;  
A4SFY4, RIBBA_CHLPM;  Q9Z734, RIBBA_CHLPN;  O84736, RIBBA_CHLTR;  
A0Q3H7, RIBBA_CLONN;  O24752, RIBBA_CORAM;  A4QEG9, RIBBA_CORGB;  
Q8NQ52, RIBBA_CORGL;  Q11WK6, RIBBA_CYTH3;  B1H0I0, RIBBA_ENDTX;  
C5D3N0, RIBBA_GEOSW;  A0QI09, RIBBA_MYCA1;  B1MCA4, RIBBA_MYCA9;  
P0A5V1, RIBBA_MYCBO;  A1KIK4, RIBBA_MYCBP;  C1AN60, RIBBA_MYCBT;  
A4TC13, RIBBA_MYCGI;  B2HP67, RIBBA_MYCMM;  Q741F1, RIBBA_MYCPA;  
A5U2B7, RIBBA_MYCTA;  P9WHF0, RIBBA_MYCTO;  P9WHF1, RIBBA_MYCTU;  
A0PPL6, RIBBA_MYCUA;  A1T8K1, RIBBA_MYCVP;  Q5YTP3, RIBBA_NOCFA;  
A6LHN0, RIBBA_PARD8;  B4SE30, RIBBA_PELPB;  A6KWQ7, RIBBA_PHOV8;  
B2RIG7, RIBBA_PORG3;  Q7MWK9, RIBBA_PORGI;  B4S5Y8, RIBBA_PROA2;  
C0ZZE5, RIBBA_RHOE4;  Q0S0K2, RIBBA_RHOJR;  A8LY38, RIBBA_SALAI;  
A4X639, RIBBA_SALTO;  Q5HF07, RIBBA_STAAC;  Q99TA0, RIBBA_STAAM;  
Q7A511, RIBBA_STAAN;  Q6GFT5, RIBBA_STAAR;  Q6G8G1, RIBBA_STAAS;  
Q8NW14, RIBBA_STAAW;  Q5HNE3, RIBBA_STAEQ;  Q8CNU2, RIBBA_STAES;  
Q4L7B1, RIBBA_STAHJ;  Q49YJ7, RIBBA_STAS1;  Q0AXM5, RIBBA_SYNWW;  
P74104, RIBBA_SYNY3;  Q9X2E6, RIBBA_THEMA;  B0KAI2, RIBBA_THEP3;  
B0K0Y9, RIBBA_THEPX;  A0KHV1, RIBB_AERHH;  A4SKH7, RIBB_AERS4;  
Q8UE66, RIBB_AGRFC;  Q9L6K8, RIBB_ALIFS;  O28173, RIBB_ARCFU;  
Q1LSL6, RIBB_BAUCH;  Q7VQQ4, RIBB_BLOFL;  Q7WDL7, RIBB_BORBR;  
Q7W2M1, RIBB_BORPA;  Q7VSF4, RIBB_BORPE;  B8D8L7, RIBB_BUCA5;  
P57167, RIBB_BUCAI;  Q8KA55, RIBB_BUCAP;  B8D6X1, RIBB_BUCAT;  
P59556, RIBB_BUCBP;  Q9PHU4, RIBB_CAMJE;  B3EEP4, RIBB_CHLL2;  
B3QWA4, RIBB_CHLT3;  Q7NQC4, RIBB_CHRVO;  A8APS7, RIBB_CITK8;  
A7FXH7, RIBB_CLOB1;  A5I603, RIBB_CLOBH;  A7GHE0, RIBB_CLOBL;  
A7MP95, RIBB_CROS8;  Q46TZ9, RIBB_CUPPJ;  C0QJB0, RIBB_DESAH;  
B8FLF4, RIBB_DESAL;  B8J4Q5, RIBB_DESDA;  Q6AQE3, RIBB_DESPS;  
A4J2L3, RIBB_DESRM;  Q72B63, RIBB_DESVH;  A1VD83, RIBB_DESVV;  
A7ZRS4, RIBB_ECO24;  B7UIV5, RIBB_ECO27;  B7MAC3, RIBB_ECO45;  
B7LGI1, RIBB_ECO55;  P0A7J1, RIBB_ECO57;  B5YR87, RIBB_ECO5E;  
B7NJQ5, RIBB_ECO7I;  B7N0J6, RIBB_ECO81;  B7LZJ1, RIBB_ECO8A;  
C4ZQV9, RIBB_ECOBW;  B1XG46, RIBB_ECODH;  A8A4J8, RIBB_ECOHS;  
A1AFX0, RIBB_ECOK1;  Q0TD60, RIBB_ECOL5;  Q8FDH9, RIBB_ECOL6;  
B1ISB5, RIBB_ECOLC;  P0A7J0, RIBB_ECOLI;  B7ND35, RIBB_ECOLU;  
B6I413, RIBB_ECOSE;  B1LF38, RIBB_ECOSM;  Q1R6T4, RIBB_ECOUT;  
C5BHH8, RIBB_EDWI9;  A4WEI2, RIBB_ENT38;  B2VGK1, RIBB_ERWT9;  
B7LQC3, RIBB_ESCF3;  Q4QMD5, RIBB_HAEI8;  A5UDW2, RIBB_HAEIE;  
A5UHR8, RIBB_HAEIG;  P44866, RIBB_HAEIN;  Q0I132, RIBB_HAES1;  
C4K8P2, RIBB_HAMD5;  Q7VJN5, RIBB_HELHP;  Q9ZL40, RIBB_HELPJ;  
O25484, RIBB_HELPY;  B0UX44, RIBB_HISS2;  B5XU43, RIBB_KLEP3;  
A6TE29, RIBB_KLEP7;  Q65W81, RIBB_MANSM;  C6BVV4, RIBB_MARSD;  
Q8TT89, RIBB_METAC;  Q60364, RIBB_METJA;  A2SQG6, RIBB_METLZ;  
Q8PW86, RIBB_METMA;  O27543, RIBB_METTH;  Q9JU97, RIBB_NEIMA;  
Q9JZ77, RIBB_NEIMB;  Q8CWF6, RIBB_OCEIH;  Q313P5, RIBB_OLEA2;  
P57940, RIBB_PASMU;  Q6D8S3, RIBB_PECAS;  C6D9P9, RIBB_PECCP;  
A1AKS6, RIBB_PELPD;  Q02008, RIBB_PHOLE;  Q7N0C8, RIBB_PHOLL;  
P51962, RIBB_PHOPO;  Q6LIW0, RIBB_PHOPR;  B4EW41, RIBB_PROMH;  
Q9HWX4, RIBB_PSEAE;  Q88QG4, RIBB_PSEPK;  Q882G0, RIBB_PSESM;  
Q3IKS6, RIBB_PSET1;  Q8XQN1, RIBB_RALSO;  Q2RS98, RIBB_RHORT;  
B5F690, RIBB_SALA4;  A9MPW6, RIBB_SALAR;  Q57JR5, RIBB_SALCH;  
B5FHS9, RIBB_SALDC;  B5QZ31, RIBB_SALEP;  B5REF3, RIBB_SALG2;  
B4TI45, RIBB_SALHS;  B4T665, RIBB_SALNS;  Q5PMU5, RIBB_SALPA;  
A9N5X2, RIBB_SALPB;  C0PYW8, RIBB_SALPC;  B5BG06, RIBB_SALPK;  
B4TVS9, RIBB_SALSV;  P66033, RIBB_SALTI;  P66032, RIBB_SALTY;  
A8GJU0, RIBB_SERP5;  B8E3W7, RIBB_SHEB2;  A3DAC1, RIBB_SHEB5;  
A6WHL6, RIBB_SHEB8;  A9KVB7, RIBB_SHEB9;  Q07WC1, RIBB_SHEFN;  
B0TMY9, RIBB_SHEHH;  A3Q8W5, RIBB_SHELP;  Q8EKF2, RIBB_SHEON;  
A8GYS3, RIBB_SHEPA;  A4Y1N7, RIBB_SHEPC;  B8CH19, RIBB_SHEPW;  
A0KRF9, RIBB_SHESA;  A8G1K1, RIBB_SHESH;  Q0HP01, RIBB_SHESM;  
Q0I0H0, RIBB_SHESR;  A1RPZ7, RIBB_SHESW;  B1KNY2, RIBB_SHEWM;  
B2U1F0, RIBB_SHIB3;  Q31WZ1, RIBB_SHIBS;  Q32BS1, RIBB_SHIDS;  
Q0T0L7, RIBB_SHIF8;  P0A7J2, RIBB_SHIFL;  Q3YXK0, RIBB_SHISS;  
Q2NWD7, RIBB_SODGM;  O68249, RIBB_SULMU;  Q3A668, RIBB_SYNC1;  
C4LDD2, RIBB_TOLAT;  B7VT10, RIBB_VIBA3;  A5F159, RIBB_VIBC3;  
Q9KKP2, RIBB_VIBCH;  C3LWX2, RIBB_VIBCM;  P16448, RIBB_VIBHA;  
Q87GR5, RIBB_VIBPA;  Q8D485, RIBB_VIBVU;  Q7MFR0, RIBB_VIBVY;  
Q8D2W5, RIBB_WIGBR;  Q7M936, RIBB_WOLSU;  A1JQV2, RIBB_YERE8;  
A7FE82, RIBB_YERP3;  Q1C377, RIBB_YERPA;  B2K2H0, RIBB_YERPB;  
Q8ZI56, RIBB_YERPE;  A9R7D2, RIBB_YERPG;  Q1CMD1, RIBB_YERPN;  
A4THU2, RIBB_YERPP;  Q665V6, RIBB_YERPS;  B1JM30, RIBB_YERPY;  

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