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ENZYME entry: EC 4.1.99.12

Accepted Name
3,4-dihydroxy-2-butanone-4-phosphate synthase
Alternative Name(s)
DHBP synthase
L-3,4-dihydroxybutan-2-one-4-phosphate synthase
Reaction catalysed
D-ribulose 5-phosphate <=> (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)
Comment(s)
  • The reaction involves an intramolecular skeletal rearrangement, with the bonds in D-ribulose 5-phosphate that connect C-3 and C-5 to C-4 being broken, C-4 being removed as formate and reconnection of C-3 and C-5.
  • The phosphorylated four-carbon product (L-3,4-dihydroxybutan-2-one 4-phosphate) is an intermediate in the biosynthesis of riboflavin.
Cross-references
BRENDA4.1.99.12
EC2PDB4.1.99.12
ExplorEnz4.1.99.12
PRIAM enzyme-specific profiles4.1.99.12
KEGG Ligand Database for Enzyme Nomenclature4.1.99.12
IUBMB Enzyme Nomenclature4.1.99.12
IntEnz4.1.99.12
MEDLINEFind literature relating to 4.1.99.12
MetaCyc4.1.99.12
Rhea expert-curated reactions4.1.99.12
UniProtKB/Swiss-Prot
Q5A3V6, RIB3_CANALQ8TG90, RIB3_PYRO7O60181, RIB3_SCHPO
Q99258, RIB3_YEASTP47924, RIBA1_ARATHQ6Z234, RIBA1_ORYSJ
Q6NLQ7, RIBA2_ARATHQ0E079, RIBA2_ORYSJA3MZA2, RIBBA_ACTP2
B3H0P8, RIBBA_ACTP7B0BTN8, RIBBA_ACTPJP50855, RIBBA_ACTPL
O66679, RIBBA_AQUAEC3P7P7, RIBBA_BACAAC3LIX7, RIBBA_BACAC
A0RIB3, RIBBA_BACAHP51695, RIBBA_BACAMQ81MB6, RIBBA_BACAN
B7JLW6, RIBBA_BACC0Q731I5, RIBBA_BACC1B7IWM5, RIBBA_BACC2
C1EQY5, RIBBA_BACC3B7HAY4, RIBBA_BACC4B7HNM8, RIBBA_BACC7
A7GSD5, RIBBA_BACCNB9IWX4, RIBBA_BACCQQ818X6, RIBBA_BACCR
Q635H0, RIBBA_BACCZQ5LHT1, RIBBA_BACFNQ64YT3, RIBBA_BACFR
Q6HE54, RIBBA_BACHKA9VG50, RIBBA_BACMKP17620, RIBBA_BACSU
Q8A528, RIBBA_BACTNA7Z675, RIBBA_BACVZC0ZKW2, RIBBA_BREBN
Q3B2I6, RIBBA_CHLL3Q9PLJ5, RIBBA_CHLMUA4SFY4, RIBBA_CHLPM
Q9Z734, RIBBA_CHLPNO84736, RIBBA_CHLTRA0Q3H7, RIBBA_CLONN
O24752, RIBBA_CORAMA4QEG9, RIBBA_CORGBQ8NQ52, RIBBA_CORGL
Q11WK6, RIBBA_CYTH3B1H0I0, RIBBA_ENDTXC5D3N0, RIBBA_GEOSW
A0QI09, RIBBA_MYCA1B1MCA4, RIBBA_MYCA9P0A5V1, RIBBA_MYCBO
A1KIK4, RIBBA_MYCBPC1AN60, RIBBA_MYCBTA4TC13, RIBBA_MYCGI
B2HP67, RIBBA_MYCMMQ741F1, RIBBA_MYCPAA5U2B7, RIBBA_MYCTA
P9WHF0, RIBBA_MYCTOP9WHF1, RIBBA_MYCTUA0PPL6, RIBBA_MYCUA
A1T8K1, RIBBA_MYCVPQ5YTP3, RIBBA_NOCFAA6LHN0, RIBBA_PARD8
B4SE30, RIBBA_PELPBA6KWQ7, RIBBA_PHOV8B2RIG7, RIBBA_PORG3
Q7MWK9, RIBBA_PORGIB4S5Y8, RIBBA_PROA2C0ZZE5, RIBBA_RHOE4
Q0S0K2, RIBBA_RHOJRA8LY38, RIBBA_SALAIA4X639, RIBBA_SALTO
Q5WH08, RIBBA_SHOC1Q5HF07, RIBBA_STAACQ99TA0, RIBBA_STAAM
Q7A511, RIBBA_STAANQ6GFT5, RIBBA_STAARQ6G8G1, RIBBA_STAAS
Q8NW14, RIBBA_STAAWQ5HNE3, RIBBA_STAEQQ8CNU2, RIBBA_STAES
Q4L7B1, RIBBA_STAHJQ49YJ7, RIBBA_STAS1Q0AXM5, RIBBA_SYNWW
P74104, RIBBA_SYNY3Q9X2E6, RIBBA_THEMAB0KAI2, RIBBA_THEP3
B0K0Y9, RIBBA_THEPXA0KHV1, RIBB_AERHHA4SKH7, RIBB_AERS4
Q8UE66, RIBB_AGRFCQ9L6K8, RIBB_ALIFSO28173, RIBB_ARCFU
Q1LSL6, RIBB_BAUCHQ7VQQ4, RIBB_BLOFLQ7WDL7, RIBB_BORBR
Q7W2M1, RIBB_BORPAQ7VSF4, RIBB_BORPEB8D8L7, RIBB_BUCA5
P57167, RIBB_BUCAIQ8KA55, RIBB_BUCAPB8D6X1, RIBB_BUCAT
P59556, RIBB_BUCBPQ9PHU4, RIBB_CAMJEB3EEP4, RIBB_CHLL2
B3QWA4, RIBB_CHLT3Q7NQC4, RIBB_CHRVOA8APS7, RIBB_CITK8
A7FXH7, RIBB_CLOB1A5I603, RIBB_CLOBHA7GHE0, RIBB_CLOBL
A7MP95, RIBB_CROS8Q46TZ9, RIBB_CUPPJC0QJB0, RIBB_DESAH
B8FLF4, RIBB_DESALB8J4Q5, RIBB_DESDAQ6AQE3, RIBB_DESPS
A4J2L3, RIBB_DESRMQ72B63, RIBB_DESVHA1VD83, RIBB_DESVV
A7ZRS4, RIBB_ECO24B7UIV5, RIBB_ECO27B7MAC3, RIBB_ECO45
B7LGI1, RIBB_ECO55P0A7J1, RIBB_ECO57B5YR87, RIBB_ECO5E
B7NJQ5, RIBB_ECO7IB7N0J6, RIBB_ECO81B7LZJ1, RIBB_ECO8A
C4ZQV9, RIBB_ECOBWB1XG46, RIBB_ECODHA8A4J8, RIBB_ECOHS
A1AFX0, RIBB_ECOK1Q0TD60, RIBB_ECOL5Q8FDH9, RIBB_ECOL6
B1ISB5, RIBB_ECOLCP0A7J0, RIBB_ECOLIB7ND35, RIBB_ECOLU
B6I413, RIBB_ECOSEB1LF38, RIBB_ECOSMQ1R6T4, RIBB_ECOUT
C5BHH8, RIBB_EDWI9A4WEI2, RIBB_ENT38B2VGK1, RIBB_ERWT9
B7LQC3, RIBB_ESCF3Q4QMD5, RIBB_HAEI8A5UDW2, RIBB_HAEIE
A5UHR8, RIBB_HAEIGP44866, RIBB_HAEINC4K8P2, RIBB_HAMD5
Q7VJN5, RIBB_HELHPQ9ZL40, RIBB_HELPJO25484, RIBB_HELPY
Q0I132, RIBB_HISS1B0UX44, RIBB_HISS2B5XU43, RIBB_KLEP3
A6TE29, RIBB_KLEP7Q65W81, RIBB_MANSMC6BVV4, RIBB_MARSD
Q8TT89, RIBB_METACQ60364, RIBB_METJAA2SQG6, RIBB_METLZ
Q8PW86, RIBB_METMAO27543, RIBB_METTHQ9JU97, RIBB_NEIMA
Q9JZ77, RIBB_NEIMBQ8CWF6, RIBB_OCEIHQ313P5, RIBB_OLEA2
P57940, RIBB_PASMUQ6D8S3, RIBB_PECASC6D9P9, RIBB_PECCP
A1AKS6, RIBB_PELPDQ02008, RIBB_PHOLEQ7N0C8, RIBB_PHOLL
P51962, RIBB_PHOPOQ6LIW0, RIBB_PHOPRB4EW41, RIBB_PROMH
Q9HWX4, RIBB_PSEAEQ88QG4, RIBB_PSEPKQ882G0, RIBB_PSESM
Q3IKS6, RIBB_PSET1Q8XQN1, RIBB_RALN1Q2RS98, RIBB_RHORT
B5F690, RIBB_SALA4A9MPW6, RIBB_SALARQ57JR5, RIBB_SALCH
B5FHS9, RIBB_SALDCB5QZ31, RIBB_SALEPB5REF3, RIBB_SALG2
B4TI45, RIBB_SALHSB4T665, RIBB_SALNSQ5PMU5, RIBB_SALPA
A9N5X2, RIBB_SALPBC0PYW8, RIBB_SALPCB5BG06, RIBB_SALPK
B4TVS9, RIBB_SALSVP66033, RIBB_SALTIP66032, RIBB_SALTY
A8GJU0, RIBB_SERP5B8E3W7, RIBB_SHEB2A3DAC1, RIBB_SHEB5
A6WHL6, RIBB_SHEB8A9KVB7, RIBB_SHEB9Q07WC1, RIBB_SHEFN
B0TMY9, RIBB_SHEHHA3Q8W5, RIBB_SHELPQ8EKF2, RIBB_SHEON
A8GYS3, RIBB_SHEPAA4Y1N7, RIBB_SHEPCB8CH19, RIBB_SHEPW
A0KRF9, RIBB_SHESAA8G1K1, RIBB_SHESHQ0HP01, RIBB_SHESM
Q0I0H0, RIBB_SHESRA1RPZ7, RIBB_SHESWB1KNY2, RIBB_SHEWM
B2U1F0, RIBB_SHIB3Q31WZ1, RIBB_SHIBSQ32BS1, RIBB_SHIDS
Q0T0L7, RIBB_SHIF8P0A7J2, RIBB_SHIFLQ3YXK0, RIBB_SHISS
Q2NWD7, RIBB_SODGMO68249, RIBB_SULMUQ3A668, RIBB_SYNC1
C4LDD2, RIBB_TOLATB7VT10, RIBB_VIBA3A5F159, RIBB_VIBC3
Q9KKP2, RIBB_VIBCHC3LWX2, RIBB_VIBCMP16448, RIBB_VIBHA
Q87GR5, RIBB_VIBPAQ8D485, RIBB_VIBVUQ7MFR0, RIBB_VIBVY
Q8D2W5, RIBB_WIGBRQ7M936, RIBB_WOLSUA1JQV2, RIBB_YERE8
A7FE82, RIBB_YERP3Q1C377, RIBB_YERPAB2K2H0, RIBB_YERPB
Q8ZI56, RIBB_YERPEA9R7D2, RIBB_YERPGQ1CMD1, RIBB_YERPN
A4THU2, RIBB_YERPPQ665V6, RIBB_YERPSB1JM30, RIBB_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
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