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ENZYME entry: EC 4.1.99.13
| Accepted Name |
|---|
| (6-4)DNA photolyase.
|
| Alternative Name(s) |
|---|
| DNA photolyase. |
| Reaction catalysed |
|---|
| (6-4) photoproduct (in DNA) <=> 2 pyrimidine residues (in DNA) |
| Comment(s) |
|---|
- The overall repair reaction consists of two distinct steps, one of
which is light-independent and the other one light-dependent.
- In the initial light-independent step, a 6-iminium ion is thought to
be generated via proton transfer induced by two histidines highly
conserved among the (6-4) photolyases.
- This intermediate spontaneously rearranges to form an oxetane
intermediate by intramolecular nucleophilic attack.
- In the subsequent light-driven reaction, one electron is believed to
be transferred from the fully reduced FAD cofactor (FADH(-)) to the
oxetane intermediate thus forming a neutral FADH radical and an
anionic oxetane radical, which spontaneously fractures.
- The excess electron is then back-transferred to the flavin radical
restoring the fully reduced flavin cofactor and a pair of pyrimidine
bases.
|
| Cross-references |
|---|
| BRENDA | 4.1.99.13 |
| EC2PDB | 4.1.99.13 |
| ExplorEnz | 4.1.99.13 |
| PRIAM enzyme-specific profiles | 4.1.99.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.99.13 |
| IUBMB Enzyme Nomenclature | 4.1.99.13 |
| IntEnz | 4.1.99.13 |
| MEDLINE | Find literature relating to 4.1.99.13 |
| MetaCyc | 4.1.99.13 |
| Rhea expert-curated reactions | 4.1.99.13 |
| UniProtKB/Swiss-Prot |
|
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