A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 188.8.131.52
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|(6-4) photoproduct (in DNA) <=> 2 pyrimidine residues (in DNA)|
- The overall repair reaction consists of two distinct steps, one of
which is light-independent and the other one light-dependent.
- In the initial light-independent step, a 6-iminium ion is thought to
be generated via proton transfer induced by two histidines highly
conserved among the (6-4) photolyases.
- This intermediate spontaneously rearranges to form an oxetane
intermediate by intramolecular nucleophilic attack.
- In the subsequent light-driven reaction, one electron is believed to
be transferred from the fully reduced FAD cofactor (FADH(-)) to the
oxetane intermediate thus forming a neutral FADH radical and an
anionic oxetane radical, which spontaneously fractures.
- The excess electron is then back-transferred to the flavin radical
restoring the fully reduced flavin cofactor and a pair of pyrimidine
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
entries corresponding to 4.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-