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ENZYME entry: EC 4.1.99.16

Accepted Name
Geosmin synthase.
Reaction catalysed
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H(2)O <=> (-)-geosmin + acetone
Cofactor(s)
Mg(2+).
Comment(s)
  • Geosmin is the cause of the characteristic smell of moist soil.
  • It is a bifunctional enzyme.
  • The N-terminal part of the enzyme is EC 4.2.3.22, germacradienol synthase, and forms germacradienol from FPP.
  • The C-terminal part of the enzyme catalyzes the conversion of germacradienol to geosmin via (1S,4aS,8aS)-8,10-dimethyl- 1,2,3,4,4a,5,6,8a-octahydronaphthalene.
Cross-references
BRENDA4.1.99.16
EC2PDB4.1.99.16
ExplorEnz4.1.99.16
PRIAM enzyme-specific profiles4.1.99.16
KEGG Ligand Database for Enzyme Nomenclature4.1.99.16
IUBMB Enzyme Nomenclature4.1.99.16
IntEnz4.1.99.16
MEDLINEFind literature relating to 4.1.99.16
MetaCyc4.1.99.16
Rhea expert-curated reactions4.1.99.16
UniProtKB/Swiss-Prot
Q9X839, CYC2_STRCO

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