A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.99.16
| Accepted Name |
|---|
| Geosmin synthase.
|
| Reaction catalysed |
|---|
| (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H(2)O <=> (-)-geosmin + acetone |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- Geosmin is the cause of the characteristic smell of moist soil.
- It is a bifunctional enzyme.
- The N-terminal part of the enzyme is EC 4.2.3.22, germacradienol
synthase, and forms germacradienol from FPP.
- The C-terminal part of the enzyme catalyzes the conversion of
germacradienol to geosmin via (1S,4aS,8aS)-8,10-dimethyl-
1,2,3,4,4a,5,6,8a-octahydronaphthalene.
|
| Cross-references |
|---|
| BRENDA | 4.1.99.16 |
| EC2PDB | 4.1.99.16 |
| ExplorEnz | 4.1.99.16 |
| PRIAM enzyme-specific profiles | 4.1.99.16 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.99.16 |
| IUBMB Enzyme Nomenclature | 4.1.99.16 |
| IntEnz | 4.1.99.16 |
| MEDLINE | Find literature relating to 4.1.99.16 |
| MetaCyc | 4.1.99.16 |
| UniProtKB/Swiss-Prot |
|
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