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ENZYME

ENZYME entry: EC 4.1.99.17

Accepted Name
phosphomethylpyrimidine synthase
Reaction catalysed
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine <=> 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine
Comment(s)
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The first stage of catalysis is reduction of the S-adenosyl-L- methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl radical that is crucial for the conversion of the substrate.
  • Part of the pathway for thiamine biosynthesis.
Cross-references
BRENDA4.1.99.17
EC2PDB4.1.99.17
ExplorEnz4.1.99.17
PRIAM enzyme-specific profiles4.1.99.17
KEGG Ligand Database for Enzyme Nomenclature4.1.99.17
IUBMB Enzyme Nomenclature4.1.99.17
IntEnz4.1.99.17
MEDLINEFind literature relating to 4.1.99.17
MetaCyc4.1.99.17
Rhea expert-curated reactions4.1.99.17
UniProtKB/Swiss-Prot
Q8TPW4, THIC1_METACQ46EW5, THIC1_METBFQ8Q0F4, THIC1_METMA
Q2NHI8, THIC1_METSTO27586, THIC1_METTHQ97YJ8, THIC1_SACS2
Q3A7P7, THIC1_SYNC1Q8TI28, THIC2_METACQ46AN2, THIC2_METBF
Q8PY39, THIC2_METMAQ2NHG6, THIC2_METSTO27617, THIC2_METTH
Q97X14, THIC2_SACS2Q3A2D2, THIC2_SYNC1B0CCG9, THIC_ACAM1
Q6FFB6, THIC_ACIADB7H1M6, THIC_ACIB3B7I331, THIC_ACIB5
B2I1W2, THIC_ACIBCB0VMD7, THIC_ACIBSA3M1D2, THIC_ACIBT
B0VDF1, THIC_ACIBYB9MFQ3, THIC_ACIETB7J7C4, THIC_ACIF2
B5EQ61, THIC_ACIF5A1WBZ7, THIC_ACISJB6JI86, THIC_AFIC5
Q8UCC9, THIC_AGRFCQ21XR6, THIC_ALBFTQ5E8W9, THIC_ALIF1
B5FF66, THIC_ALIFMB6EGV1, THIC_ALISLA6TVU5, THIC_ALKMQ
A8MEI9, THIC_ALKOOB9K253, THIC_ALLAMB4S2W4, THIC_ALTMD
B8JAC3, THIC_ANAD2Q2IID8, THIC_ANADEA7HCC3, THIC_ANADF
Q5PB42, THIC_ANAMMQ2GKB1, THIC_ANAPZB4UDM7, THIC_ANASK
O67259, THIC_AQUAEO82392, THIC_ARATHO30259, THIC_ARCFU
Q5P6L3, THIC_AROAEA1K3Q2, THIC_AZOSBC3P178, THIC_BACAA
C3LEJ7, THIC_BACACA0RL17, THIC_BACAHQ81WY7, THIC_BACAN
B7JGF0, THIC_BACC0P61423, THIC_BACC1B7IPY9, THIC_BACC2
C1EZL5, THIC_BACC3B7HEM8, THIC_BACC4B7HX62, THIC_BACC7
A7GUZ5, THIC_BACCNB9J5N4, THIC_BACCQQ815D5, THIC_BACCR
Q631C7, THIC_BACCZQ5LCA5, THIC_BACFNQ64T99, THIC_BACFR
Q6HB59, THIC_BACHKQ65M65, THIC_BACLDA9VR68, THIC_BACMK
A8FFR8, THIC_BACP2P45740, THIC_BACSUQ8AA15, THIC_BACTN
A7Z2P5, THIC_BACVZA1US11, THIC_BARBKQ6G477, THIC_BARHE
Q6G099, THIC_BARQUA9IRH7, THIC_BART1Q1LU45, THIC_BAUCH
Q2L083, THIC_BORA1Q7WQM6, THIC_BORBRQ7W1Q0, THIC_BORPA
A9IFG8, THIC_BORPDQ7W0D7, THIC_BORPEQ89FP0, THIC_BRADU
A5EPQ5, THIC_BRASBA4YZQ6, THIC_BRASOB1YW60, THIC_BURA4
A0K648, THIC_BURCHB4ED40, THIC_BURCJQ0BGQ9, THIC_BURCM
Q39HY9, THIC_BURL3A9ACX9, THIC_BURM1A3MIG6, THIC_BURM7
A2S3Z6, THIC_BURM9Q62FE9, THIC_BURMAA1V2S9, THIC_BURMS
B1JYX0, THIC_BURO0Q1BXK3, THIC_BURO1A3NTK3, THIC_BURP0
Q3JU20, THIC_BURP1A3N7W7, THIC_BURP6Q63VF5, THIC_BURPS
Q2SUP3, THIC_BURTAA4JCZ0, THIC_BURVGQ8R9P1, THIC_CALS4
A0RN29, THIC_CAMFFA7I162, THIC_CAMHCA8FKN8, THIC_CAMJ8
A7H4T0, THIC_CAMJDQ9PI55, THIC_CAMJEA1VYG9, THIC_CAMJJ
Q5HW14, THIC_CAMJRQ3AE33, THIC_CARHZB0T2Q1, THIC_CAUSK
Q9A6Q5, THIC_CAUVCB8GX84, THIC_CAUVNB3PCK0, THIC_CELJU
Q3ATM0, THIC_CHLCHB3EE09, THIC_CHLL2Q3B2V9, THIC_CHLL3
B3QPT5, THIC_CHLP8B3EPH6, THIC_CHLPBA4SFM6, THIC_CHLPM
Q8KCH9, THIC_CHLTEQ7P1H8, THIC_CHRVOA8AKS9, THIC_CITK8
Q97EU2, THIC_CLOABA7FXG9, THIC_CLOB1C3L2Y4, THIC_CLOB6
A5I5Z5, THIC_CLOBHC1FVP6, THIC_CLOBJB1ILH9, THIC_CLOBK
A7GHD2, THIC_CLOBLB1KZJ7, THIC_CLOBMQ186R0, THIC_CLOD6
B9E2H5, THIC_CLOK1A5N937, THIC_CLOK5A0Q1U9, THIC_CLONN
Q0TTB7, THIC_CLOP1Q8XMK9, THIC_CLOPEQ0SV55, THIC_CLOPS
Q897B2, THIC_CLOTEQ48A96, THIC_COLP3P61424, THIC_CORDI
Q8FPT3, THIC_COREFA4QDR7, THIC_CORGBQ8NQW7, THIC_CORGL
Q4JVZ0, THIC_CORJKB6J5W3, THIC_COXB1B6J1X8, THIC_COXB2
A9KGN7, THIC_COXBNQ83EJ0, THIC_COXBUB1WW40, THIC_CROS5
Q1LS28, THIC_CUPMCQ0KF34, THIC_CUPNHQ476U6, THIC_CUPPJ
B2AGF3, THIC_CUPTRB8HNW1, THIC_CYAP4Q478T2, THIC_DECAR
Q3Z8E2, THIC_DEHM1A5FR94, THIC_DEHMBQ3ZXE1, THIC_DEHMC
Q1IX15, THIC_DEIGDQ9RYX8, THIC_DEIRAB1I672, THIC_DESAP
B8FUD2, THIC_DESHDA8ZVP4, THIC_DESOHQ6AK99, THIC_DESPS
A4J8J1, THIC_DESRMA7ZUK9, THIC_ECO24B7UPE9, THIC_ECO27
B7MIY0, THIC_ECO45B7LA88, THIC_ECO55Q8X6X9, THIC_ECO57
B5Z090, THIC_ECO5EB7NRS7, THIC_ECO7IB7MRC0, THIC_ECO81
B7M7Q3, THIC_ECO8AC5A0T5, THIC_ECOBWB1XBZ7, THIC_ECODH
A8A794, THIC_ECOHSA1AIG5, THIC_ECOK1Q0TA71, THIC_ECOL5
Q8FB77, THIC_ECOL6B1IUQ3, THIC_ECOLCP30136, THIC_ECOLI
B7NFT5, THIC_ECOLUB6I5K5, THIC_ECOSEB1LNU6, THIC_ECOSM
Q3YSI0, THIC_EHRCJQ2GG37, THIC_EHRCRQ5FHG9, THIC_EHRRG
Q5HBN2, THIC_EHRRWQ2N8D9, THIC_ERYLHB7LUK8, THIC_ESCF3
B0S3A6, THIC_FINM2Q2JG22, THIC_FRACCQ8RI60, THIC_FUSNN
Q5L325, THIC_GEOKAQ39RJ6, THIC_GEOMGC5D571, THIC_GEOSW
A4IK74, THIC_GEOTNB7KDN8, THIC_GLOC7Q7NLK5, THIC_GLOVI
Q5FNT7, THIC_GLUOXQ2SQL8, THIC_HAHCHQ9KBJ4, THIC_HALH5
Q5V2X0, THIC_HALMAB0R400, THIC_HALS3Q9HRG2, THIC_HALSA
Q7VFU4, THIC_HELHPA4G224, THIC_HERARQ31JC9, THIC_HYDCU
Q5QUD0, THIC_IDILOA8A8N6, THIC_IGNH4A6SUX7, THIC_JANMA
B5XYE4, THIC_KLEP3A6TGQ1, THIC_KLEP7Q04VF1, THIC_LEPBJ
Q04Y23, THIC_LEPBLB1Y5I3, THIC_LEPCPQ72NZ8, THIC_LEPIC
Q8F7G5, THIC_LEPINA6UT74, THIC_META3A7I8Q1, THIC_METB6
Q603T9, THIC_METCAQ2FQY7, THIC_METHJQ58432, THIC_METJA
Q8TZ33, THIC_METKAA2SU66, THIC_METLZA4G002, THIC_METM5
A9A8A9, THIC_METM6A6VIH6, THIC_METM7A3CVT7, THIC_METMJ
P61428, THIC_METMPB8GKY4, THIC_METPEA2SG83, THIC_METPP
A6URG5, THIC_METVSB0JSK4, THIC_MICANQ2RIM5, THIC_MOOTA
A0QLS0, THIC_MYCA1B1MIP8, THIC_MYCA9P66912, THIC_MYCBO
A1KFP5, THIC_MYCBPC1AK99, THIC_MYCBTB8ZU90, THIC_MYCLB
Q9ZBL0, THIC_MYCLEB2HQM5, THIC_MYCMMP61426, THIC_MYCPA
A5TZE9, THIC_MYCTAP9WG78, THIC_MYCTOP9WG79, THIC_MYCTU
A0PTS1, THIC_MYCUAQ1D4L3, THIC_MYXXDQ3IRP7, THIC_NATPD
B9L811, THIC_NAUPAQ5F588, THIC_NEIG1A9M0A4, THIC_NEIM0
Q9JWF3, THIC_NEIMAQ9JXI0, THIC_NEIMBA1KWC0, THIC_NEIMF
Q0AJI9, THIC_NITECQ82Y50, THIC_NITEUQ1QJD3, THIC_NITHX
Q2Y6P4, THIC_NITMUQ3J7C1, THIC_NITOCA6Q2K1, THIC_NITSB
Q3SPS0, THIC_NITWNQ5YNS3, THIC_NOCFAB2J323, THIC_NOSP7
Q8YY69, THIC_NOSS1Q2G7A9, THIC_NOVADA1TKD9, THIC_PARC0
A1B684, THIC_PARDPA7HV30, THIC_PARL1Q2WAV0, THIC_PARM1
Q7U9W2, THIC_PARMWB2JJF7, THIC_PARP8B2SXY6, THIC_PARPJ
Q13WN4, THIC_PARXLQ6DAM0, THIC_PECASB4SBF6, THIC_PELPB
A5D4K5, THIC_PELTSQ7N963, THIC_PHOLLQ6LVY0, THIC_PHOPR
B1XIG4, THIC_PICP2A1VI67, THIC_POLNAQ12HI8, THIC_POLSJ
B2RH34, THIC_PORG3Q7MT71, THIC_PORGIB4S9A9, THIC_PROA2
A3PFA2, THIC_PROM0A2C559, THIC_PROM1A8G7B7, THIC_PROM2
A2C642, THIC_PROM3A9BD54, THIC_PROM4A2BYZ5, THIC_PROM5
Q318D0, THIC_PROM9Q7V9Q8, THIC_PROMAQ7V906, THIC_PROMM
Q7UZP7, THIC_PROMPA2BTJ3, THIC_PROMSQ46IK0, THIC_PROMT
Q48P32, THIC_PSE14A6VD86, THIC_PSEA7B7V362, THIC_PSEA8
Q02F45, THIC_PSEABQ9HUJ2, THIC_PSEAEQ1I419, THIC_PSEE4
Q4KJA1, THIC_PSEF5A8F821, THIC_PSELTA4XPW1, THIC_PSEMY
A5W9V8, THIC_PSEP1Q3KJ20, THIC_PSEPFB0KL24, THIC_PSEPG
Q88DA5, THIC_PSEPKB1JAG3, THIC_PSEPWQ87VG1, THIC_PSESM
Q3IFN9, THIC_PSET1Q4ZZ08, THIC_PSEU2Q4FVJ8, THIC_PSYA2
Q1QEM6, THIC_PSYCKQ9V0X8, THIC_PYRABQ8ZZC0, THIC_PYRAE
Q8U0Q4, THIC_PYRFUQ8Y368, THIC_RALN1Q2K206, THIC_RHIEC
Q98AZ3, THIC_RHILOQ92TI9, THIC_RHIMEB9JMY1, THIC_RHIR8
A5VB82, THIC_RHIWRQ7UP26, THIC_RHOBAQ2IYP8, THIC_RHOP2
Q07PX1, THIC_RHOP5P61427, THIC_RHOPAQ216H0, THIC_RHOPB
Q133T3, THIC_RHOPSB3QFS9, THIC_RHOPTQ2RST7, THIC_RHORT
B7K508, THIC_RIPO1Q1GEY0, THIC_RUESTA1AW65, THIC_RUTMC
Q21NU6, THIC_SACD2B5F1H7, THIC_SALA4A9MHD6, THIC_SALAR
Q57H61, THIC_SALCHB5FQK9, THIC_SALDCB5QYE9, THIC_SALEP
B5RFJ0, THIC_SALG2B4TCT3, THIC_SALHSB4T0Z6, THIC_SALNS
Q5PKA6, THIC_SALPAA9N0K6, THIC_SALPBC0Q2S6, THIC_SALPC
B5BJR3, THIC_SALPKB4TQK4, THIC_SALSVQ8Z326, THIC_SALTI
Q9L9I7, THIC_SALTYA1S6Q9, THIC_SHEAMQ12NC2, THIC_SHEDO
B0TRP7, THIC_SHEHHA3QER4, THIC_SHELPQ8EED7, THIC_SHEON
A8H566, THIC_SHEPAA4Y6R2, THIC_SHEPCA8FUU9, THIC_SHESH
B1KHI4, THIC_SHEWMB2TWI1, THIC_SHIB3Q31U03, THIC_SHIBS
Q32AG7, THIC_SHIDSQ0SY06, THIC_SHIF8Q83PB8, THIC_SHIFL
Q3YUZ0, THIC_SHISSQ028Z8, THIC_SOLUEQ1GQJ3, THIC_SPHAL
Q82FI7, THIC_STRAWQ9X9U0, THIC_STRCOB1VPA3, THIC_STRGG
B4SI60, THIC_STRM5B2FT70, THIC_STRMKA4VR38, THIC_STUS1
Q4JCB9, THIC_SULACQ30QG8, THIC_SULDNC3N4K5, THIC_SULIA
C4KG47, THIC_SULIKC3MMC3, THIC_SULILC3MX60, THIC_SULIM
Q96ZH0, THIC_SULTOQ2LSU0, THIC_SYNASQ31P93, THIC_SYNE7
Q2JY68, THIC_SYNJAQ2JPK6, THIC_SYNJBQ5N4X6, THIC_SYNP6
A5GI51, THIC_SYNPWA5GQ73, THIC_SYNR3Q0IDV6, THIC_SYNS3
Q3B0I6, THIC_SYNS9Q3AND3, THIC_SYNSCQ0AZ84, THIC_SYNWW
Q55894, THIC_SYNY3C5BTK7, THIC_TERTTC5A6A9, THIC_THEGJ
Q5JD26, THIC_THEKOQ9WZP5, THIC_THEMAB9KAI3, THIC_THENN
A5IIZ7, THIC_THEP1B0KD66, THIC_THEP3B0K5Z9, THIC_THEPX
B1LCP2, THIC_THESQQ72KP6, THIC_THET2Q5SKG5, THIC_THET8
Q8DLZ2, THIC_THEVBB5YJ75, THIC_THEYDQ3SFG3, THIC_THIDA
Q111Z9, THIC_TRIEIQ3MGA3, THIC_TRIV2C5CM74, THIC_VARPS
A5CX15, THIC_VESOHB7VMV7, THIC_VIBA3A7N141, THIC_VIBC1
A5F4D2, THIC_VIBC3Q9KVS8, THIC_VIBCHC3LPQ3, THIC_VIBCM
Q87KF0, THIC_VIBPAQ8DDL4, THIC_VIBVUQ7MGM3, THIC_VIBVY
Q8D247, THIC_WIGBRQ7M818, THIC_WOLSUQ8PH13, THIC_XANAC
Q4UYF2, THIC_XANC8B0RP37, THIC_XANCBQ8P5L9, THIC_XANCP
Q3BPK7, THIC_XANE5Q2P755, THIC_XANOMB2SNG3, THIC_XANOP
Q5H4C0, THIC_XANORQ9PC93, THIC_XYLFAQ87CY6, THIC_XYLFT
Q8ZAQ2, THIC_YERPEQ66FP5, THIC_YERPSQ5NR58, THIC_ZYMMO
Q8G7X1, THIEC_BIFLO

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