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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
2-iminoacetate synthase.
Reaction catalysed
L-tyrosine + S-adenosyl-L-methionine + NADPH <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+) + H(+)
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The first stage of catalysis is reduction of the S-adenosyl-L- methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate.
  • Part of the pathway for thiamine biosynthesis.
  • Formerly EC 1.3.99.n2.
PRIAM enzyme-specific profiles4.1.99.19
KEGG Ligand Database for Enzyme Nomenclature4.1.99.19
IUBMB Enzyme Nomenclature4.1.99.19
MEDLINEFind literature relating to
P30140, THIH_ECOLI;  Q9S498, THIH_SALTY;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-