ENZYME entry: EC 4.1.99.23
| Accepted Name |
|---|
| 5-hydroxybenzimidazole synthase.
|
| Alternative Name(s) |
|---|
| HBI synthase. |
| Reaction catalysed |
|---|
| 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor <=> 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + formate + NH(3) + phosphate + oxidized acceptor |
| Comment(s) |
|---|
- The enzyme, purified from bacteria, is part of the anaerobic pathway
for cobalamin biosynthesis.
- It binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an
exchangeable S-adenosyl-L-methionine molecule.
- The first stage of catalysis is reduction of the S-adenosyl-L-
methionine to produce L-methionine and a 5'-deoxyadenosin-5'-yl
radical that is crucial for the conversion of the substrate.
|
| Cross-references |
|---|
| BRENDA | 4.1.99.23 |
| EC2PDB | 4.1.99.23 |
| ExplorEnz | 4.1.99.23 |
| PRIAM enzyme-specific profiles | 4.1.99.23 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.99.23 |
| IUBMB Enzyme Nomenclature | 4.1.99.23 |
| IntEnz | 4.1.99.23 |
| MEDLINE | Find literature relating to 4.1.99.23 |
| MetaCyc | 4.1.99.23 |
| UniProtKB/Swiss-Prot |
|
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