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ENZYME

ENZYME entry: EC 4.2.1.1

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.1
Accepted Name
carbonic anhydrase
Alternative Name(s)
carbonate dehydratase
carbonate hydro-lyase
carbonic dehydratase
Reaction catalysed
hydrogencarbonate + H(+) = CO2 + H2O
Comment(s)
  • The enzyme catalyzes the reversible hydration of dissolved CO2 to carbonic acid, which dissociates to give hydrogencarbonate above neutral pH.
  • It is widespread and found in archaea, bacteria, and eukaryotes.
  • Three distinct classes exist, and appear to have evolved independently.
  • Contains zinc.
Cross-references
BRENDA4.2.1.1
EC2PDB4.2.1.1
ExplorEnz4.2.1.1
KEGG Ligand Database for Enzyme Nomenclature4.2.1.1
IUBMB Enzyme Nomenclature4.2.1.1
MEDLINEFind literature relating to 4.2.1.1
MetaCyc4.2.1.1
Rhea expert-curated reactions4.2.1.1
UniProtKB/Swiss-Prot
O04846, ATCA1_ARATHF4IHR4, ATCA2_ARATHQ9FYE3, ATCA3_ARATH
F4JIK2, ATCA4_ARATHF4HUC4, ATCA5_ARATHQ9SUB4, ATCA6_ARATH
Q8L817, ATCA7_ARATHQ9FM99, ATCA8_ARATHP27140, BCA1_ARATH
A8XKV0, BCA1_CAEBRQ22460, BCA1_CAEELP42737, BCA2_ARATH
Q9ZUC2, BCA3_ARATHQ94CE4, BCA4_ARATHQ94CE3, BCA5_ARATH
Q9C6F5, BCA6_ARATHQ5KW03, CAG_GEOKAO43570, CAH12_HUMAN
Q8CI85, CAH12_MOUSEQ9MZ30, CAH12_RABITQ8N1Q1, CAH13_HUMAN
Q9D6N1, CAH13_MOUSEQ9ULX7, CAH14_HUMANQ9WVT6, CAH14_MOUSE
Q99N23, CAH15_MOUSEQ1LZA1, CAH1_BOVINP83299, CAH1_CHIHA
P20507, CAH1_CHLREP46512, CAH1_FLALIQ7M316, CAH1_GORGO
P00917, CAH1_HORSEP00915, CAH1_HUMANB3A0P2, CAH1_LOTGI
P00916, CAH1_MACMUP35217, CAH1_MACNEQ8HY33, CAH1_MONDO
P13634, CAH1_MOUSEQ7M317, CAH1_PANTRP07452, CAH1_RABIT
B0BNN3, CAH1_RATP48282, CAH1_SHEEPP00921, CAH2_BOVIN
P07630, CAH2_CHICKP24258, CAH2_CHLREP46513, CAH2_FLALI
P00918, CAH2_HUMANB3A0Q6, CAH2_LOTGIP00920, CAH2_MOUSE
Q8UWA5, CAH2_PSEHKP00919, CAH2_RABITP27139, CAH2_RAT
P00922, CAH2_SHEEPQ3SZX4, CAH3_BOVINQ27504, CAH3_CAEEL
P07450, CAH3_HORSEP07451, CAH3_HUMANP16015, CAH3_MOUSE
Q5S1S4, CAH3_PIGP14141, CAH3_RATQ95323, CAH4_BOVIN
P22748, CAH4_HUMANQ64444, CAH4_MOUSEP48283, CAH4_RABIT
P48284, CAH4_RATP35218, CAH5A_HUMANP23589, CAH5A_MOUSE
P43165, CAH5A_RATQ9Y2D0, CAH5B_HUMANQ9QZA0, CAH5B_MOUSE
Q66HG6, CAH5B_RATQ10462, CAH5_CAEELP18915, CAH6_BOVIN
Q865C0, CAH6_CANLFP23280, CAH6_HUMANP18761, CAH6_MOUSE
P08060, CAH6_SHEEPP43166, CAH7_HUMANQ9ERQ8, CAH7_MOUSE
Q16790, CAH9_HUMANQ8VHB5, CAH9_MOUSEP40880, CAHC_HORVU
P17067, CAHC_PEAP16016, CAHC_SPIOLP27141, CAHC_TOBAC
P46510, CAHX_FLABIP46511, CAHX_FLABRP46281, CAHX_FLAPR
Q92051, CAHZ_DANREB8V7P3, CAH_ACRMIP54212, CAH_DUNSA
O52535, CAH_KLEPNP84537, CAH_LOBCSQ57752, CAH_METJA
P40881, CAH_METTTQ50940, CAH_NEIGOP94170, CAH_NOSS1
Q6DAJ6, CAH_PECASO52538, CAH_PECCAQ5AJ71, CAN_CANAL
P61517, CAN_ECOLIQ5BCC5, CAN_EMENIP45148, CAN_HAEIN
O94255, CAN_SCHPOP61518, CAN_SHIFLP53615, CAN_YEAST
Q8YYI3, CCMM_NOSS1Q8DKB5, CCMM_THEVBO85042, CSOCA_HALNC
Q31HD6, CSOCA_HYDCUQ7TTT8, CSOCA_PARMWQ7V6G1, CSOCA_PROMM
Q7V2C7, CSOCA_PROMPP0ABF0, CYNT_ECO57P0ABE9, CYNT_ECOLI
Q9ZN54, CYNT_HELPJO24855, CYNT_HELPYA0R566, CYNT_MYCS2
Q9I262, CYNT_PSEAEP83329, CYNT_STRTRP27134, CYNT_SYNE7
Q54735, CYNT_SYNY3Q75N34, DB3S_DIOPOA7MAQ2, DIOA3_DIOJA
Q9NL38, MA66_PINMAA0ZSF6, MAC1_CRANIA0ZSF7, MAC2_CRANI
A0ZSF2, MAF_PINFUA0ZSF3, MAM_PINMAQ27908, MANA_PINFU
A0ZSF4, MAP1_MIZYEA0ZSF5, MAP2_MIZYEQ8YT18, MICAH_NOSS1
P64798, MTCA1_MYCBOP9WPJ6, MTCA1_MYCTOP9WPJ7, MTCA1_MYCTU
P9WPJ8, MTCA2_MYCTOP9WPJ9, MTCA2_MYCTUP0DO50, NEC1_NESMA
Q84UV8, NEC3_NICLSO34872, YTIB_BACSUO06983, YVDA_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
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