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ENZYME entry: EC 4.2.1.1

Accepted Name
Carbonic anhydrase.
Alternative Name(s)
Carbonate dehydratase.
Carbonate hydro-lyase.
Carbonic dehydratase.
Reaction catalysed
H(2)CO(3) <=> CO(2) + H(2)O
Cofactor(s)
Zn(2+).
Comment(s)
  • The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH.
  • It is widespread and found in archaea, bacteria, and eukaryotes.
  • Three distinct classes exist, and appear to have evolved independently.
Cross-references
PROSITEPDOC00146 ; PDOC00586
BRENDA4.2.1.1
EC2PDB4.2.1.1
ExplorEnz4.2.1.1
PRIAM enzyme-specific profiles4.2.1.1
KEGG Ligand Database for Enzyme Nomenclature4.2.1.1
IUBMB Enzyme Nomenclature4.2.1.1
IntEnz4.2.1.1
MEDLINEFind literature relating to 4.2.1.1
MetaCyc4.2.1.1
UniProtKB/Swiss-Prot
O04846, ATCA1_ARATH;  F4IHR4, ATCA2_ARATH;  Q9FYE3, ATCA3_ARATH;  
F4JIK2, ATCA4_ARATH;  F4HUC4, ATCA5_ARATH;  Q9SUB4, ATCA6_ARATH;  
Q8L817, ATCA7_ARATH;  Q9FM99, ATCA8_ARATH;  P27140, BCA1_ARATH;  
A8XKV0, BCA1_CAEBR;  Q22460, BCA1_CAEEL;  P42737, BCA2_ARATH;  
Q9ZUC2, BCA3_ARATH;  Q94CE4, BCA4_ARATH;  Q94CE3, BCA5_ARATH;  
Q9C6F5, BCA6_ARATH;  O43570, CAH12_HUMAN;  Q8CI85, CAH12_MOUSE;  
Q9MZ30, CAH12_RABIT;  Q8N1Q1, CAH13_HUMAN;  Q9D6N1, CAH13_MOUSE;  
Q9ULX7, CAH14_HUMAN;  Q9WVT6, CAH14_MOUSE;  Q99N23, CAH15_MOUSE;  
Q1LZA1, CAH1_BOVIN;  P83299, CAH1_CHIHA;  P20507, CAH1_CHLRE;  
P46512, CAH1_FLALI;  Q7M316, CAH1_GORGO;  P00917, CAH1_HORSE;  
P00915, CAH1_HUMAN;  B3A0P2, CAH1_LOTGI;  P00916, CAH1_MACMU;  
P35217, CAH1_MACNE;  Q8HY33, CAH1_MONDO;  P13634, CAH1_MOUSE;  
Q7M317, CAH1_PANTR;  P07452, CAH1_RABIT;  B0BNN3, CAH1_RAT;  
P48282, CAH1_SHEEP;  P00921, CAH2_BOVIN;  P07630, CAH2_CHICK;  
P24258, CAH2_CHLRE;  P46513, CAH2_FLALI;  P00918, CAH2_HUMAN;  
B3A0Q6, CAH2_LOTGI;  P00920, CAH2_MOUSE;  P00919, CAH2_RABIT;  
P27139, CAH2_RAT;  P00922, CAH2_SHEEP;  Q8UWA5, CAH2_TRIHK;  
Q3SZX4, CAH3_BOVIN;  Q27504, CAH3_CAEEL;  P07450, CAH3_HORSE;  
P07451, CAH3_HUMAN;  P16015, CAH3_MOUSE;  Q5S1S4, CAH3_PIG;  
P14141, CAH3_RAT;  Q95323, CAH4_BOVIN;  P22748, CAH4_HUMAN;  
Q64444, CAH4_MOUSE;  P48283, CAH4_RABIT;  P48284, CAH4_RAT;  
P35218, CAH5A_HUMAN;  P23589, CAH5A_MOUSE;  P43165, CAH5A_RAT;  
Q9Y2D0, CAH5B_HUMAN;  Q9QZA0, CAH5B_MOUSE;  Q66HG6, CAH5B_RAT;  
Q10462, CAH5_CAEEL;  P18915, CAH6_BOVIN;  Q865C0, CAH6_CANLF;  
P23280, CAH6_HUMAN;  P18761, CAH6_MOUSE;  P08060, CAH6_SHEEP;  
P43166, CAH7_HUMAN;  Q9ERQ8, CAH7_MOUSE;  Q16790, CAH9_HUMAN;  
Q8VHB5, CAH9_MOUSE;  P40880, CAHC_HORVU;  P17067, CAHC_PEA;  
P16016, CAHC_SPIOL;  P27141, CAHC_TOBAC;  P46510, CAHX_FLABI;  
P46511, CAHX_FLABR;  P46281, CAHX_FLAPR;  Q92051, CAHZ_DANRE;  
B8V7P3, CAH_ACRMI;  P54212, CAH_DUNSA;  O52535, CAH_KLEPN;  
P84537, CAH_LOBCS;  P40881, CAH_METTE;  Q50940, CAH_NEIGO;  
P94170, CAH_NOSS1;  Q6DAJ6, CAH_PECAS;  O52538, CAH_PECCA;  
Q5AJ71, CAN_CANAL;  P61517, CAN_ECOLI;  Q5BCC5, CAN_EMENI;  
P45148, CAN_HAEIN;  O94255, CAN_SCHPO;  P61518, CAN_SHIFL;  
P53615, CAN_YEAST;  P0ABF0, CYNT_ECO57;  P0ABE9, CYNT_ECOLI;  
Q9ZN54, CYNT_HELPJ;  O24855, CYNT_HELPY;  A0R566, CYNT_MYCS2;  
Q9I262, CYNT_PSEAE;  P83329, CYNT_STRTR;  P27134, CYNT_SYNE7;  
Q54735, CYNT_SYNY3;  Q9NL38, MA66_PINMA;  A0ZSF6, MAC1_CRANI;  
A0ZSF7, MAC2_CRANI;  A0ZSF2, MAF_PINFU;  A0ZSF3, MAM_PINMA;  
Q27908, MANA_PINFU;  A0ZSF4, MAP1_MIZYE;  A0ZSF5, MAP2_MIZYE;  
P9WPJ6, MTCA1_MYCTO;  P9WPJ7, MTCA1_MYCTU;  P9WPJ8, MTCA2_MYCTO;  
P9WPJ9, MTCA2_MYCTU;  Q84UV8, NEC3_NICLS;  O34872, YTIB_BACSU;  
O06983, YVDA_BACSU;  

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