A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
Lyases
Carbon-oxygen lyases
Hydro-lyases
The following ENZYME entries belong to class 4.2.1.-:
4.2.1.1 Carbonic anhydrase 4.2.1.2 Fumarate hydratase 4.2.1.3 Aconitate hydratase 4.2.1.4 Transferred entry: 4.2.1.3 4.2.1.5 Arabinonate dehydratase 4.2.1.6 Galactonate dehydratase 4.2.1.7 Altronate dehydratase 4.2.1.8 Mannonate dehydratase 4.2.1.9 Dihydroxy-acid dehydratase 4.2.1.10 3-dehydroquinate dehydratase 4.2.1.11 Phosphopyruvate hydratase 4.2.1.12 Phosphogluconate dehydratase 4.2.1.13 Transferred entry: 4.3.1.17 4.2.1.14 Transferred entry: 4.3.1.18 4.2.1.15 Transferred entry: 4.4.1.1 4.2.1.16 Transferred entry: 4.3.1.19 4.2.1.17 Enoyl-CoA hydratase 4.2.1.18 Methylglutaconyl-CoA hydratase 4.2.1.19 Imidazoleglycerol-phosphate dehydratase 4.2.1.20 Tryptophan synthase 4.2.1.21 Transferred entry: 4.2.1.22 4.2.1.22 Cystathionine beta-synthase 4.2.1.23 Deleted entry 4.2.1.24 Porphobilinogen synthase 4.2.1.25 L-arabinonate dehydratase 4.2.1.26 Transferred entry: 4.3.1.9 4.2.1.27 Acetylenecarboxylate hydratase 4.2.1.28 Propanediol dehydratase 4.2.1.29 Transferred entry: 4.99.1.6 4.2.1.30 Glycerol dehydratase 4.2.1.31 Maleate hydratase 4.2.1.32 L(+)-tartrate dehydratase 4.2.1.33 3-isopropylmalate dehydratase 4.2.1.34 (S)-2-methylmalate dehydratase 4.2.1.35 (R)-2-methylmalate dehydratase 4.2.1.36 Homoaconitate hydratase 4.2.1.37 Transferred entry: 3.3.2.4 4.2.1.38 Transferred entry: 4.3.1.20 4.2.1.39 Gluconate dehydratase 4.2.1.40 Glucarate dehydratase 4.2.1.41 5-dehydro-4-deoxyglucarate dehydratase 4.2.1.42 Galactarate dehydratase 4.2.1.43 2-dehydro-3-deoxy-L-arabinonate dehydratase 4.2.1.44 Myo-inosose-2 dehydratase 4.2.1.45 CDP-glucose 4,6-dehydratase 4.2.1.46 dTDP-glucose 4,6-dehydratase 4.2.1.47 GDP-mannose 4,6-dehydratase 4.2.1.48 D-glutamate cyclase 4.2.1.49 Urocanate hydratase 4.2.1.50 Pyrazolylalanine synthase 4.2.1.51 Prephenate dehydratase 4.2.1.52 Transferred entry: 4.3.3.7 4.2.1.53 Oleate hydratase 4.2.1.54 Lactoyl-CoA dehydratase 4.2.1.55 3-hydroxybutyryl-CoA dehydratase 4.2.1.56 Itaconyl-CoA hydratase 4.2.1.57 Isohexenylglutaconyl-CoA hydratase 4.2.1.58 Transferred entry: 4.2.1.59 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase 4.2.1.60 Transferred entry: 4.2.1.59 4.2.1.61 Transferred entry: 4.2.1.59 4.2.1.62 5-alpha-hydroxysteroid dehydratase 4.2.1.63 Transferred entry: 3.3.2.9 and 3.3.2.10 4.2.1.64 Transferred entry: 3.3.2.9 and 3.3.2.10 4.2.1.65 3-cyanoalanine hydratase 4.2.1.66 Cyanide hydratase 4.2.1.67 D-fuconate dehydratase 4.2.1.68 L-fuconate dehydratase 4.2.1.69 Cyanamide hydratase 4.2.1.70 Pseudouridylate synthase 4.2.1.71 Transferred entry: 4.2.1.27 4.2.1.72 Transferred entry: 4.1.1.78 4.2.1.73 Protoaphin-aglucone dehydratase (cyclizing) 4.2.1.74 Long-chain-enoyl-CoA hydratase 4.2.1.75 Uroporphyrinogen-III synthase 4.2.1.76 UDP-glucose 4,6-dehydratase 4.2.1.77 Trans-L-3-hydroxyproline dehydratase 4.2.1.78 (S)-norcoclaurine synthase 4.2.1.79 2-methylcitrate dehydratase 4.2.1.80 2-oxopent-4-enoate hydratase 4.2.1.81 D(-)-tartrate dehydratase 4.2.1.82 Xylonate dehydratase 4.2.1.83 4-oxalmesaconate hydratase 4.2.1.84 Nitrile hydratase 4.2.1.85 Dimethylmaleate hydratase 4.2.1.86 Transferred entry: 4.2.1.98 4.2.1.87 Octopamine dehydratase 4.2.1.88 (R)-synephrine 4.2.1.89 Transferred entry: 2.8.3.21 and 4.2.1.149 4.2.1.90 L-rhamnonate dehydratase 4.2.1.91 Arogenate dehydratase 4.2.1.92 Hydroperoxide dehydratase 4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase 4.2.1.94 Scytalone dehydratase 4.2.1.95 Kievitone hydratase 4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase 4.2.1.97 Phaseollidin hydratase 4.2.1.98 16-alpha-hydroxyprogesterone dehydratase 4.2.1.99 2-methylisocitrate dehydratase 4.2.1.100 Cyclohexa-1,5-dienecarbonyl-CoA hydratase 4.2.1.101 Trans-feruloyl-CoA hydratase 4.2.1.102 Transferred entry: 4.2.1.100 4.2.1.103 Cyclohexyl-isocyanide hydratase 4.2.1.104 Cyanase 4.2.1.105 2-hydroxyisoflavanone dehydratase 4.2.1.106 Bile-acid 7-alpha-dehydratase 4.2.1.107 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase 4.2.1.108 Ectoine synthase 4.2.1.109 Methylthioribulose 1-phosphate dehydratase 4.2.1.110 Aldos-2-ulose dehydratase 4.2.1.111 1,5-anhydro-D-fructose dehydratase 4.2.1.112 Acetylene hydratase 4.2.1.113 o-succinylbenzoate synthase 4.2.1.114 Methanogen homoaconitase 4.2.1.115 UDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.116 3-hydroxypropionyl-CoA dehydratase 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) 4.2.1.118 3-dehydroshikimate dehydratase 4.2.1.119 Enoyl-CoA hydratase 2 4.2.1.120 4-hydroxybutanoyl-CoA dehydratase 4.2.1.121 Colneleate synthase 4.2.1.122 Tryptophan synthase (indole-salvaging) 4.2.1.123 Tetrahymanol synthase 4.2.1.124 Arabidiol synthase 4.2.1.125 Dammarenediol II synthase 4.2.1.126 N-acetylmuramic acid 6-phosphate etherase 4.2.1.127 Linalool dehydratase 4.2.1.128 Lupan-3-beta,20-diol synthase 4.2.1.129 Squalene--hopanol cyclase 4.2.1.130 D-lactate dehydratase 4.2.1.131 Carotenoid 1,2-hydratase 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase 4.2.1.133 Copal-8-ol diphosphate hydratase 4.2.1.134 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4.2.1.135 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining) 4.2.1.136 ADP-dependent NAD(P)H-hydrate dehydratase 4.2.1.137 Sporulenol synthase 4.2.1.138 (+)-caryolan-1-ol synthase 4.2.1.139 Medicarpin synthase 4.2.1.140 Gluconate/galactonate dehydratase 4.2.1.141 2-dehydro-3-deoxy-D-arabinonate dehydratase 4.2.1.142 5'-oxoaverantin cyclase 4.2.1.143 Versicolorin B synthase 4.2.1.144 3-amino-5-hydroxybenzoate synthase 4.2.1.145 Capreomycidine synthase 4.2.1.146 L-galactonate dehydratase 4.2.1.147 5,6,7,8-tetrahydromethanopterin hydro-lyase 4.2.1.148 2-methylfumaryl-CoA hydratase 4.2.1.149 Crotonobetainyl-CoA hydratase 4.2.1.150 Short-chain-enoyl-CoA hydratase 4.2.1.151 Chorismate dehydratase 4.2.1.152 Hydroperoxy icosatetraenoate dehydratase 4.2.1.153 3-methylfumaryl-CoA hydratase 4.2.1.154 Tetracenomycin F2 cyclase 4.2.1.155 Methylthioacryloyl-CoA hydratase 4.2.1.156 L-talarate dehydratase 4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydratase 4.2.1.158 Galactarate dehydratase (D-threo-forming) 4.2.1.159 dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase 4.2.1.160 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase 4.2.1.161 Bisanhydrobacterioruberin hydratase 4.2.1.162 6-deoxy-6-sulfo-D-gluconate dehydratase 4.2.1.163 2-oxo-hept-4-ene-1,7-dioate hydratase 4.2.1.164 dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase 4.2.1.165 Chlorophyllide a 3(1)-hydratase 4.2.1.166 Phosphinomethylmalate isomerase 4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase 4.2.1.168 GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase 4.2.1.169 3-vinylbacteriochlorophyllide d 3(1)-hydratase 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase 4.2.1.171 Cis-l-3-hydroxyproline dehydratase 4.2.1.172 Trans-4-hydroxy-L-proline dehydratase 4.2.1.173 Ent-8-alpha-hydroxylabd-13-en-15-yl diphosphate synthase 4.2.1.174 Peregrinol diphosphate synthase 4.2.1.n1 Transferred entry: 4.2.1.126 4.2.1.n2 Transferred entry: 4.2.1.134