ENZYME

ENZYME entry: EC 4.2.1.107

Accepted Name

3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase.

Alternative Name(s)

D-3-hydroxyacyl-CoA dehydratase.

Reaction catalysed

(24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA <=> (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O

Comment(s)

Forms part of the rat peroxisomal multifunctional enzyme perMFE-2, which also exhibits a dehydrogenase activity.
Involved in the beta-oxidation of the cholesterol side chain in the cholic-acid biosynthesis pathway.

Cross-references

BRENDA

4.2.1.107

EC2PDB

4.2.1.107

ExplorEnz

4.2.1.107

PRIAM enzyme-specific profiles

4.2.1.107

KEGG Ligand Database for Enzyme Nomenclature

4.2.1.107

IUBMB Enzyme Nomenclature

4.2.1.107

IntEnz

4.2.1.107

MEDLINE

Find literature relating to 4.2.1.107

MetaCyc

4.2.1.107

UniProtKB/Swiss-Prot

P51659, DHB4_HUMAN;

P51660, DHB4_MOUSE;

P97852, DHB4_RAT;

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-