ENZYME entry: EC 4.2.1.107
| Accepted Name |
|---|
| 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA
hydratase.
|
| Alternative Name(s) |
|---|
| D-3-hydroxyacyl-CoA dehydratase. |
| Reaction catalysed |
|---|
| (24R,25R)-3-alpha,7-alpha,12-alpha,24-tetrahydroxy-5-beta-cholestanoyl-CoA <=> (24E)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA + H(2)O |
| Comment(s) |
|---|
- Forms part of the rat peroxisomal multifunctional enzyme perMFE-2,
which also exhibits a dehydrogenase activity.
- Involved in the beta-oxidation of the cholesterol side chain in the
cholic-acid biosynthesis pathway.
|
| Cross-references |
|---|
| BRENDA | 4.2.1.107 |
| EC2PDB | 4.2.1.107 |
| ExplorEnz | 4.2.1.107 |
| PRIAM enzyme-specific profiles | 4.2.1.107 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.107 |
| IUBMB Enzyme Nomenclature | 4.2.1.107 |
| IntEnz | 4.2.1.107 |
| MEDLINE | Find literature relating to 4.2.1.107 |
| MetaCyc | 4.2.1.107 |
| Rhea expert-curated reactions | 4.2.1.107 |
| UniProtKB/Swiss-Prot |
|
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