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ENZYME entry: EC 4.2.1.119

Accepted Name
enoyl-CoA hydratase 2
Alternative Name(s)
2-enoyl-CoA hydratase 2
D-3-hydroxyacyl-CoA hydro-lyase
D-specific 2-trans-enoyl-CoA hydratase
ECH2
Reaction catalysed
a (3R)-3-hydroxyacyl-CoA <=> a (2E)-enoyl-CoA + H2O
Comment(s)
  • This enzyme catalyzes a hydration step in peroxisomal beta-oxidation.
  • The human multifunctional enzyme type 2 (MFE-2) is a 79000 Da enzyme composed of three functional units: (3R)-hydroxyacyl-CoA dehydrogenase, 2-enoyl-CoA hydratase 2 and sterol carrier protein 2-like units.
  • The enzymes from Aeromonas caviae and Arabidopsis thaliana are monofunctional enzymes.
  • 2-enoyl-CoA hydratase 3 from Candida tropicalis is a part from multifunctional enzyme type 2.
Cross-references
BRENDA4.2.1.119
EC2PDB4.2.1.119
ExplorEnz4.2.1.119
PRIAM enzyme-specific profiles4.2.1.119
KEGG Ligand Database for Enzyme Nomenclature4.2.1.119
IUBMB Enzyme Nomenclature4.2.1.119
IntEnz4.2.1.119
MEDLINEFind literature relating to 4.2.1.119
MetaCyc4.2.1.119
Rhea expert-curated reactions4.2.1.119
UniProtKB/Swiss-Prot
Q9VXJ0, DHB4_DROMEP51659, DHB4_HUMANP51660, DHB4_MOUSE
P97852, DHB4_RATQ8VYI3, ECH2_ARATHP22414, FOX2_CANTR
Q01373, FOX2_NEUCRQ02207, FOX2_YEASTO53664, HTDX_MYCTU
I6YBZ8, HTDY_MYCTUQ7U2S5, HTDZ_MYCBOP9WNP2, HTDZ_MYCTO
P9WNP3, HTDZ_MYCTUQ54XZ0, MFEB_DICDIO32472, PHAJ_AERCA
Q2RQ36, PHAJ_RHORT

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