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ENZYME

ENZYME entry: EC 4.2.1.130

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.130
Accepted Name
D-lactate dehydratase
Alternative Name(s)
glyoxylase III
Reaction catalysed
methylglyoxal + H2O = (R)-lactate + H(+)
Comment(s)
  • The enzyme, described from the fungi Candida albicans and Schizosaccharomyces pombe, converts 2-oxopropanal to (R)-lactate in a single glutathione (GSH)-independent step.
  • The other known route for this conversion is the two-step GSH- dependent pathway catalyzed by EC 4.4.1.5 and EC 3.1.2.6.
Cross-references
BRENDA4.2.1.130
EC2PDB4.2.1.130
ExplorEnz4.2.1.130
KEGG Ligand Database for Enzyme Nomenclature4.2.1.130
IUBMB Enzyme Nomenclature4.2.1.130
MEDLINEFind literature relating to 4.2.1.130
MetaCyc4.2.1.130
Rhea expert-curated reactions4.2.1.130
UniProtKB/Swiss-Prot
P90994, DJ11_CAEELO16228, DJ12_CAEELQ10356, DJ1_SCHPO
P31658, HCHA_ECOLIQ5AF03, HSP31_CANALO74914, HSP31_SCHPO
Q04432, HSP31_YEASTQ09675, HSP32_SCHPOQ08992, HSP32_YEAST
O43084, HSP33_SCHPOQ08914, HSP33_YEASTQ10092, HSP34_SCHPO
Q09918, HSP35_SCHPOQ04902, SNO4_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-