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ENZYME entry: EC 4.2.1.150

Accepted Name
Short-chain-enoyl-CoA hydratase.
Alternative Name(s)
3-hydroxybutyryl-CoA dehydratase.
Crotonase.
Reaction catalysed
A short-chain (3S)-3-hydroxyacyl-CoA <=> a short-chain trans-2-enoyl-CoA + H(2)O
Comment(s)
  • The enzyme from the bacterium Clostridium acetobutylicum is part of the central fermentation pathway and plays a key role in the production of both acids and solvents.
  • It is specific for short, C(4)-C(6), chain length substrates and exhibits an extremely high turnover number for crotonyl-CoA.
  • Cf. EC 4.2.1.17 and EC 4.2.1.74.
Cross-references
BRENDA4.2.1.150
EC2PDB4.2.1.150
ExplorEnz4.2.1.150
PRIAM enzyme-specific profiles4.2.1.150
KEGG Ligand Database for Enzyme Nomenclature4.2.1.150
IUBMB Enzyme Nomenclature4.2.1.150
IntEnz4.2.1.150
MEDLINEFind literature relating to 4.2.1.150
MetaCyc4.2.1.150
UniProtKB/Swiss-Prot
Q0AVM1, CRCH_SYNWW;  P52046, CRT_CLOAB;  P45361, CRT_CLODI;  
P81357, CRT_CLOPA;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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