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ENZYME entry: EC 4.2.1.157

Accepted Name
(R)-2-hydroxyisocaproyl-CoA dehydratase.
Alternative Name(s)
2-hydroxyisocaproyl-CoA dehydratase.
Reaction catalysed
(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O
Comment(s)
  • The enzyme, isolated from the bacterium Peptoclostridium difficile, is involved in the reductive branch of L-leucine fermentation.
  • It catalyzes an alpha/beta-dehydration, which depends on the reductive formation of ketyl radicals on the substrate generated by injection of a single electron from the ATP-dependent activator protein HadI.
Cross-references
BRENDA4.2.1.157
EC2PDB4.2.1.157
ExplorEnz4.2.1.157
PRIAM enzyme-specific profiles4.2.1.157
KEGG Ligand Database for Enzyme Nomenclature4.2.1.157
IUBMB Enzyme Nomenclature4.2.1.157
IntEnz4.2.1.157
MEDLINEFind literature relating to 4.2.1.157
MetaCyc4.2.1.157
Rhea expert-curated reactions4.2.1.157
UniProtKB/Swiss-Prot
Q5U924, HADB_CLODI;  Q5U923, HADC_CLODI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-