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ENZYME entry: EC 4.2.1.157
Accepted Name |
(R)-2-hydroxyisocaproyl-CoA dehydratase.
|
Alternative Name(s) |
2-hydroxyisocaproyl-CoA dehydratase. |
Reaction catalysed |
(R)-2-hydroxy-4-methylpentanoyl-CoA <=> 4-methylpent-2-enoyl-CoA + H2O |
Comment(s) |
- The enzyme, isolated from the bacterium Peptoclostridium difficile,
is involved in the reductive branch of L-leucine fermentation.
- It catalyzes an alpha/beta-dehydration, which depends on the
reductive formation of ketyl radicals on the substrate generated by
injection of a single electron from the ATP-dependent activator
protein HadI.
|
Cross-references |
BRENDA | 4.2.1.157 |
EC2PDB | 4.2.1.157 |
ExplorEnz | 4.2.1.157 |
PRIAM enzyme-specific profiles | 4.2.1.157 |
KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.157 |
IUBMB Enzyme Nomenclature | 4.2.1.157 |
IntEnz | 4.2.1.157 |
MEDLINE | Find literature relating to 4.2.1.157 |
MetaCyc | 4.2.1.157 |
Rhea expert-curated reactions | 4.2.1.157 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
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