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ENZYME entry: EC 4.2.1.167

Accepted Name
(R)-2-hydroxyglutaryl-CoA dehydratase.
Reaction catalysed
(R)-2-hydroxyglutaryl-CoA <=> (E)-glutaconyl-CoA + H(2)O
Comment(s)
  • The enzymes from the bacteria Acidaminococcus fermentans and Clostridium symbiosum are involved in the fermentation of L-glutamate.
  • The enzyme contains (4F-4S) clusters, FMNH(2) and riboflavin.
  • It must be activated by a an activator protein.
  • Once activated, it can catalyze many turnovers.
Cross-references
BRENDA4.2.1.167
EC2PDB4.2.1.167
ExplorEnz4.2.1.167
PRIAM enzyme-specific profiles4.2.1.167
KEGG Ligand Database for Enzyme Nomenclature4.2.1.167
IUBMB Enzyme Nomenclature4.2.1.167
IntEnz4.2.1.167
MEDLINEFind literature relating to 4.2.1.167
MetaCyc4.2.1.167
UniProtKB/Swiss-Prot
P11569, HGDA_ACIFV;  P11570, HGDB_ACIFV;  

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