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ENZYME entry: EC 4.2.1.22

Accepted Name
Cystathionine beta-synthase.
Alternative Name(s)
Beta-thionase.
Methylcysteine synthase.
Serine sulfhydrase.
Reaction catalysed
L-serine + L-homocysteine <=> L-cystathionine + H(2)O
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans.
  • Formerly EC 4.2.1.21.
Cross-references
PROSITEPDOC00700
BRENDA4.2.1.22
EC2PDB4.2.1.22
ExplorEnz4.2.1.22
PRIAM enzyme-specific profiles4.2.1.22
KEGG Ligand Database for Enzyme Nomenclature4.2.1.22
IUBMB Enzyme Nomenclature4.2.1.22
IntEnz4.2.1.22
MEDLINEFind literature relating to 4.2.1.22
MetaCyc4.2.1.22
UniProtKB/Swiss-Prot
P0DN79, CBSL_HUMAN;  P46794, CBS_DICDI;  P35520, CBS_HUMAN;  
Q58H57, CBS_MACFA;  Q91WT9, CBS_MOUSE;  Q9N0V7, CBS_RABIT;  
P32232, CBS_RAT;  P32582, CBS_YEAST;  Q9YBL2, CYSO_AERPE;  
P9WP50, Y1077_MYCTO;  P9WP51, Y1077_MYCTU;  

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