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ENZYME

ENZYME entry: EC 4.2.1.24

Accepted Name
porphobilinogen synthase
Alternative Name(s)
aminolevulinate dehydratase
delta-aminolevulinic acid dehydratase
Reaction catalysed
2 5-aminolevulinate <=> H(+) + 2 H2O + porphobilinogen
Comment(s)
  • The enzyme catalyzes the asymmetric condensation and cyclization of two 5-aminolevulinate molecules, which is the first common step in the biosynthesis of tetrapyrrole pigments such as porphyrin, chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430.
  • The enzyme is widespread, being essential in organisms that carry out respiration, photosynthesis, or methanogenesis.
  • In humans, the enzyme is a primary target for the environmental toxin Pb.
  • The enzymes from some organisms utilize a dynamic equilibrium between architecturally distinct multimeric assemblies as a means for allosteric regulation.
Cross-references
BRENDA4.2.1.24
EC2PDB4.2.1.24
ExplorEnz4.2.1.24
PRIAM enzyme-specific profiles4.2.1.24
KEGG Ligand Database for Enzyme Nomenclature4.2.1.24
IUBMB Enzyme Nomenclature4.2.1.24
IntEnz4.2.1.24
MEDLINEFind literature relating to 4.2.1.24
MetaCyc4.2.1.24
Rhea expert-curated reactions4.2.1.24
UniProtKB/Swiss-Prot
Q9SFH9, HEM21_ARATHQ94LA4, HEM22_ARATHO67876, HEM2_AQUAE
O28305, HEM2_ARCFUQ750E0, HEM2_ASHGOP30950, HEM2_BACSU
Q58DK5, HEM2_BOVINP45622, HEM2_BRADUO42768, HEM2_CANGB
Q9PLU4, HEM2_CHLMUQ59334, HEM2_CHLP8Q9Z7G1, HEM2_CHLPN
Q42682, HEM2_CHLREQ8KCJ0, HEM2_CHLTEO84638, HEM2_CHLTR
Q55E06, HEM2_DICDIP0ACB2, HEM2_ECOLIQ9K8G2, HEM2_HALH5
Q9ZMR8, HEM2_HELPJP56074, HEM2_HELPYQ42836, HEM2_HORVU
P13716, HEM2_HUMANQ60HH9, HEM2_MACFAQ60178, HEM2_METJA
Q02250, HEM2_METSCO26839, HEM2_METTHP10518, HEM2_MOUSE
P46723, HEM2_MYCLEP9WMP4, HEM2_MYCTOP9WMP5, HEM2_MYCTU
Q5Z8V9, HEM2_ORYSJP30124, HEM2_PEAQ43058, HEM2_PHYPA
Q5R971, HEM2_PONABP77923, HEM2_PROFFQ59643, HEM2_PSEAE
P06214, HEM2_RATP42504, HEM2_RHOCAQ59295, HEM2_RUMJO
P78974, HEM2_SCHPOP45623, HEM2_SELMAP0ACB3, HEM2_SHIFL
P43210, HEM2_SOYBNP24493, HEM2_SPIOLQ2FXR3, HEM2_STAA8
Q5HFA4, HEM2_STAACP64333, HEM2_STAAMP64334, HEM2_STAAN
Q6GG37, HEM2_STAARQ6G8Q7, HEM2_STAASP0C1R9, HEM2_STAAU
P64335, HEM2_STAAWQ5HNN5, HEM2_STAEQQ8CNZ0, HEM2_STAES
P54919, HEM2_STRCOP43087, HEM2_SYNE7P77969, HEM2_SYNY3
P05373, HEM2_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-