- The enzyme catalyzes the asymmetric condensation and cyclization of
two 5-aminolevulinate molecules, which is the first common step in
the biosynthesis of tetrapyrrole pigments such as porphyrin,
chlorophyll, vitamin B12, siroheme, phycobilin, and cofactor F430.
- The enzyme is widespread, being essential in organisms that carry out
respiration, photosynthesis, or methanogenesis.
- In humans, the enzyme is a primary target for the environmental toxin
Pb.
- The enzymes from some organisms utilize a dynamic equilibrium between
architecturally distinct multimeric assemblies as a means for
allosteric regulation.
|
| UniProtKB/Swiss-Prot |
| Q9SFH9, HEM21_ARATH; | Q94LA4, HEM22_ARATH; | O67876, HEM2_AQUAE; |
| O28305, HEM2_ARCFU; | Q750E0, HEM2_ASHGO; | Q9K8G2, HEM2_BACHD; |
| P30950, HEM2_BACSU; | Q58DK5, HEM2_BOVIN; | P45622, HEM2_BRADU; |
| O42768, HEM2_CANGA; | Q9PLU4, HEM2_CHLMU; | Q59334, HEM2_CHLP8; |
| Q9Z7G1, HEM2_CHLPN; | Q42682, HEM2_CHLRE; | Q8KCJ0, HEM2_CHLTE; |
| O84638, HEM2_CHLTR; | Q55E06, HEM2_DICDI; | P0ACB2, HEM2_ECOLI; |
| Q9ZMR8, HEM2_HELPJ; | P56074, HEM2_HELPY; | Q42836, HEM2_HORVU; |
| P13716, HEM2_HUMAN; | Q60HH9, HEM2_MACFA; | Q60178, HEM2_METJA; |
| Q02250, HEM2_METSC; | O26839, HEM2_METTH; | P10518, HEM2_MOUSE; |
| P46723, HEM2_MYCLE; | P9WMP4, HEM2_MYCTO; | P9WMP5, HEM2_MYCTU; |
| Q5Z8V9, HEM2_ORYSJ; | P30124, HEM2_PEA; | Q43058, HEM2_PHYPA; |
| Q5R971, HEM2_PONAB; | P77923, HEM2_PROFF; | Q59643, HEM2_PSEAE; |
| P06214, HEM2_RAT; | P42504, HEM2_RHOCA; | Q59295, HEM2_RUMJO; |
| P78974, HEM2_SCHPO; | P45623, HEM2_SELMA; | P0ACB3, HEM2_SHIFL; |
| P43210, HEM2_SOYBN; | P24493, HEM2_SPIOL; | Q2FXR3, HEM2_STAA8; |
| Q5HFA4, HEM2_STAAC; | P64333, HEM2_STAAM; | P64334, HEM2_STAAN; |
| Q6GG37, HEM2_STAAR; | Q6G8Q7, HEM2_STAAS; | P0C1R9, HEM2_STAAU; |
| P64335, HEM2_STAAW; | Q5HNN5, HEM2_STAEQ; | Q8CNZ0, HEM2_STAES; |
| P54919, HEM2_STRCO; | P43087, HEM2_SYNE7; | P77969, HEM2_SYNY3; |
| P05373, HEM2_YEAST; |
|