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ENZYME entry: EC 4.2.1.27

Accepted Name
Acetylenecarboxylate hydratase.
Alternative Name(s)
Acetylenemonocarboxylate hydratase.
Alkynoate hydratase.
Malonate-semialdehyde dehydratase.
Reaction catalysed
3-oxopropanoate <=> propynoate + H(2)O
Comment(s)
  • The reaction is effectively irreversible, favoring oxopropanoate (malonic semialdehyde) and its tautomers.
  • Also acts on but-3-ynoate forming acetoacetate.
  • The mechanism appears to involve hydration of the acetylene to 3-hydroxypropenoate, which will spontaneously tautomerize to 3-oxopropanoate.
  • It is thus analogous to EC 4.1.1.78 in its mechanism.
  • Formerly EC 4.2.1.71.
Cross-references
BRENDA4.2.1.27
EC2PDB4.2.1.27
ExplorEnz4.2.1.27
PRIAM enzyme-specific profiles4.2.1.27
KEGG Ligand Database for Enzyme Nomenclature4.2.1.27
IUBMB Enzyme Nomenclature4.2.1.27
IntEnz4.2.1.27
MEDLINEFind literature relating to 4.2.1.27
MetaCyc4.2.1.27
Rhea expert-curated reactions4.2.1.27

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-