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ENZYME

ENZYME entry: EC 4.2.1.47

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.47
Accepted Name
GDP-mannose 4,6-dehydratase
Alternative Name(s)
GDP-D-mannose 4,6-dehydratase
GDP-D-mannose dehydratase
guanosine 5'-diphosphate-D-mannose oxidoreductase
guanosine diphosphomannose 4,6-dehydratase
guanosine diphosphomannose oxidoreductase
Reaction catalysed
GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O
Comment(s)
  • Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose.
  • In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.
Cross-references
BRENDA4.2.1.47
EC2PDB4.2.1.47
ExplorEnz4.2.1.47
KEGG Ligand Database for Enzyme Nomenclature4.2.1.47
IUBMB Enzyme Nomenclature4.2.1.47
MEDLINEFind literature relating to 4.2.1.47
MetaCyc4.2.1.47
Rhea expert-curated reactions4.2.1.47
UniProtKB/Swiss-Prot
Q9JRN5, GM4D_AGGACP0AC90, GM4D_ECO57P0AC89, GM4D_ECOL6
P0AC88, GM4D_ECOLIQ51366, GM4D_PSEAEP0AC91, GM4D_SHIFL
O85713, GM4D_SINF1P55354, GM4D_SINFNQ06952, GM4D_VIBCH
Q56598, GM4D_VIBCLQ56872, GM4D_YERE8Q9SNY3, GMD1_ARATH
A8Y0L5, GMD1_CAEBRQ18801, GMD1_CAEELP93031, GMD2_ARATH
O45583, GMD2_CAEELQ8K3X3, GMDS_CRIGRQ1ZXF7, GMDS_DICDI
Q9VMW9, GMDS_DROMEO60547, GMDS_HUMANQ8K0C9, GMDS_MOUSE
A0A1B4XBH2, SDNI_SORAA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-