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ENZYME

ENZYME entry: EC 4.2.1.70

Accepted Name
pseudouridylate synthase
Alternative Name(s)
pseudouridine-5'-phosphate glycosidase
pseudouridine synthase
uracil hydrolyase
Reaction catalysed
D-ribose 5-phosphate + uracil = psi-UMP + H2O
Comment(s)
  • The reaction it readily reversible.
  • While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.
Cross-references
BRENDA4.2.1.70
EC2PDB4.2.1.70
ExplorEnz4.2.1.70
PRIAM enzyme-specific profiles4.2.1.70
KEGG Ligand Database for Enzyme Nomenclature4.2.1.70
IUBMB Enzyme Nomenclature4.2.1.70
IntEnz4.2.1.70
MEDLINEFind literature relating to 4.2.1.70
MetaCyc4.2.1.70
Rhea expert-curated reactions4.2.1.70
UniProtKB/Swiss-Prot
Q7N4X5, PSUG1_PHOLLQ1MFZ6, PSUG1_RHIJ3Q7MZE1, PSUG2_PHOLL
Q1M4T3, PSUG2_RHIJ3A9NGD7, PSUG_ACHLIA6TL60, PSUG_ALKMQ
B8JB61, PSUG_ANAD2C0QZV6, PSUG_BRAHWC0ZIY1, PSUG_BREBN
Q8RCT3, PSUG_CALS4B9LGZ1, PSUG_CHLSYA7GCK7, PSUG_CLOBL
B5Y6G9, PSUG_COPPDB3GW58, PSUG_CORA7Q46PS3, PSUG_CUPPJ
Q9RS16, PSUG_DEIRAC6CFY1, PSUG_DICC1Q9L393, PSUG_DICD3
A8LQI0, PSUG_DINSHP33025, PSUG_ECOLIA7HMA1, PSUG_FERNB
Q0RBB8, PSUG_FRAAAC1AA54, PSUG_GEMATQ5L078, PSUG_GEOKA
B8F668, PSUG_GLAP5Q2SM69, PSUG_HAHCHA9B4S4, PSUG_HERA2
Q28PY7, PSUG_JANSCC5CDZ1, PSUG_KOSOTQ5ZU79, PSUG_LEGPH
B1HV79, PSUG_LYSSCB8II14, PSUG_METNOA5IXG3, PSUG_MYCAP
Q1D739, PSUG_MYXXDA1SQN1, PSUG_NOCSJA1B316, PSUG_PARDP
A9BJN0, PSUG_PETMOA8F8N4, PSUG_PSELTQ98NQ8, PSUG_RHILO
B6IRJ4, PSUG_RHOCSQ165S4, PSUG_ROSDOA5UT22, PSUG_ROSS1
Q1AYR4, PSUG_RUBXDA4F929, PSUG_SACENA4X4Y7, PSUG_SALTO
A8GCG3, PSUG_SERP5Q01RY8, PSUG_SOLUEA9GT78, PSUG_SORC5
Q8NYD0, PSUG_STAAWB1W0X1, PSUG_STRGGQ67N11, PSUG_SYMTH
B7ID34, PSUG_THEABQ9X1H5, PSUG_THEMAB9K8C2, PSUG_THENN
A5IMC0, PSUG_THEP1B1LBK3, PSUG_THESQQ72JF9, PSUG_THET2
Q84K35, PUMY_ARATHQ9USY1, YOW5_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-