A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 220.127.116.11
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|Chondroitin ABC eliminase.|
|Chondroitin ABC lyase.|
|Chondroitin sulfate ABC exoeliminase.|
|Chondroitin sulfate ABC exolyase.|
|Chondroitin sulfate ABC lyase.|
|ChS ABC lyase.|
|ChS ABC lyase II.|
|Exolytic removal of Delta(4)-unsaturated disaccharide residues from the non-reducing ends of both polymeric chondroitin/dermatan sulfates and their oligosaccharide fragments|
- Degrades a variety of glycosaminoglycans of the chondroitin-sulfate-
and dermatan-sulfate type.
- Chondroitin sulfate, chondroitin-sulfate proteoglycan and dermatan
sulfate are the best substrates but the enzyme can also act on
hyaluronan at a much lower rate.
- The related enzyme EC 18.104.22.168 has the same substrate specificity but
produces a mixture of oligosaccharides of different sizes that are
ultimately degraded to tetra- and disaccharides.
- Both enzymes act by the removal of a relatively acidic C-5 proton of
the uronic acid followed by the elimination of a 4-linked hexosamine,
resulting in the formation of an unsaturated C4-C5 bond on the
hexuronic acid moiety of the products.
- Formerly EC 22.214.171.124 and EC 126.96.36.199.
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-