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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.2.2.3

Accepted Name
Mannuronate-specific alginate lyase.
Alternative Name(s)
Alginate lyase I.
Poly(beta-D-mannuronate) lyase.
Poly(mana) alginate lyase.
Reaction catalysed
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at their reducing end
Comment(s)
  • The enzyme catalyzes the degradation of alginate by a beta- elimination reaction.
  • It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non- reducing ends and beta-D-mannuronate at the reducing end.
  • Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products.
  • Cf. EC 4.2.2.11.
  • Formerly EC 4.2.99.4.
Cross-references
BRENDA4.2.2.3
EC2PDB4.2.2.3
ExplorEnz4.2.2.3
PRIAM enzyme-specific profiles4.2.2.3
KEGG Ligand Database for Enzyme Nomenclature4.2.2.3
IUBMB Enzyme Nomenclature4.2.2.3
IntEnz4.2.2.3
MEDLINEFind literature relating to 4.2.2.3
MetaCyc4.2.2.3
UniProtKB/Swiss-Prot
Q9ZFG9, ALGE7_AZOVI;  O50660, ALGL_AZOCH;  C1DP89, ALGL_AZOVD;  
O52195, ALGL_AZOVI;  Q9ZNB7, ALGL_COBMA;  A6V1P7, ALGL_PSEA7;  
B7UUU9, ALGL_PSEA8;  Q02R18, ALGL_PSEAB;  Q06749, ALGL_PSEAE;  
Q1I563, ALGL_PSEE4;  Q4KHY5, ALGL_PSEF5;  P59786, ALGL_PSEFL;  
C3KDZ3, ALGL_PSEFS;  A5W8V4, ALGL_PSEP1;  Q3KHR0, ALGL_PSEPF;  
B0KGQ9, ALGL_PSEPG;  Q88ND1, ALGL_PSEPK;  B1J479, ALGL_PSEPW;  
Q887Q5, ALGL_PSESM;  Q9L7P2, ALGL_PSESY;  Q4ZXL0, ALGL_PSEU2;  
P39049, ALXM_PHOS4;  Q59478, ALYA_KLEPN;  Q59639, ALYA_PSEAL;  
Q06365, ALYP_PSESO;  B2FHL8, PL_STRMK;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-