Expasy logo

ENZYME

ENZYME entry: EC 4.2.2.3

PURL: https://purl.expasy.org/enzyme/EC/4.2.2.3
Accepted Name
mannuronate-specific alginate lyase
Alternative Name(s)
alginate lyase I
poly(beta-D-mannuronate) lyase
poly(mana) alginate lyase
Reaction catalysed
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at their reducing end
Comment(s)
  • The enzyme catalyzes the degradation of alginate by a beta- elimination reaction.
  • It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non- reducing ends and beta-D-mannuronate at the reducing end.
  • Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11.
  • Formerly EC 4.2.99.4.
Cross-references
Rhea expert-curated reactions4.2.2.3
ExplorEnz4.2.2.3
IUBMB Enzyme Nomenclature4.2.2.3
UniProtKB/Swiss-Prot
Q9ZFG9, ALGE7_AZOVIO50660, ALGL_AZOCHC1DP89, ALGL_AZOVD
O52195, ALGL_AZOVIQ9ZNB7, ALGL_COBMAB7UUU9, ALGL_PSEA8
Q02R18, ALGL_PSEABQ06749, ALGL_PSEAEQ1I563, ALGL_PSEE4
Q4KHY5, ALGL_PSEF5P59786, ALGL_PSEFLC3KDZ3, ALGL_PSEFS
A5W8V4, ALGL_PSEP1A6V1P7, ALGL_PSEP7Q3KHR0, ALGL_PSEPF
B0KGQ9, ALGL_PSEPGQ88ND1, ALGL_PSEPKB1J479, ALGL_PSEPW
Q887Q5, ALGL_PSESMQ9L7P2, ALGL_PSESYQ4ZXL0, ALGL_PSEU2
P39049, ALXM_PHOS4Q59478, ALYA_KLEPNQ59639, ALYA_PSEAL
Q06365, ALYP_PSESOB2FHL8, PL_STRMK
BRENDA4.2.2.3
MetaCyc4.2.2.3
KEGG Ligand Database for Enzyme Nomenclature4.2.2.3
EC2PDB4.2.2.3
MEDLINEFind literature relating to 4.2.2.3

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-