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ENZYME

ENZYME entry: EC 4.2.2.3

PURL: https://purl.expasy.org/enzyme/EC/4.2.2.3
Accepted Name
mannuronate-specific alginate lyase
Alternative Name(s)
alginate lyase I
poly(beta-D-mannuronate) lyase
poly(mana) alginate lyase
Reaction catalysed
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and beta-D-mannuronate at their reducing end
Comment(s)
  • The enzyme catalyzes the degradation of alginate by a beta- elimination reaction.
  • It cleaves the (1->4) bond between beta-D-mannuronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non- reducing ends and beta-D-mannuronate at the reducing end.
  • Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to four residues, with preference for shorter products. cf. EC 4.2.2.11.
  • Formerly EC 4.2.99.4.
Cross-references
BRENDA4.2.2.3
EC2PDB4.2.2.3
ExplorEnz4.2.2.3
KEGG Ligand Database for Enzyme Nomenclature4.2.2.3
IUBMB Enzyme Nomenclature4.2.2.3
MEDLINEFind literature relating to 4.2.2.3
MetaCyc4.2.2.3
Rhea expert-curated reactions4.2.2.3
UniProtKB/Swiss-Prot
Q9ZFG9, ALGE7_AZOVIO50660, ALGL_AZOCHC1DP89, ALGL_AZOVD
O52195, ALGL_AZOVIQ9ZNB7, ALGL_COBMAB7UUU9, ALGL_PSEA8
Q02R18, ALGL_PSEABQ06749, ALGL_PSEAEQ1I563, ALGL_PSEE4
Q4KHY5, ALGL_PSEF5P59786, ALGL_PSEFLC3KDZ3, ALGL_PSEFS
A5W8V4, ALGL_PSEP1A6V1P7, ALGL_PSEP7Q3KHR0, ALGL_PSEPF
B0KGQ9, ALGL_PSEPGQ88ND1, ALGL_PSEPKB1J479, ALGL_PSEPW
Q887Q5, ALGL_PSESMQ9L7P2, ALGL_PSESYQ4ZXL0, ALGL_PSEU2
P39049, ALXM_PHOS4Q59478, ALYA_KLEPNQ59639, ALYA_PSEAL
Q06365, ALYP_PSESOB2FHL8, PL_STRMK

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-