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ENZYME entry: EC 4.2.2.11

Accepted Name
guluronate-specific alginate lyase.
Alternative Name(s)
alginase II.
poly(alpha-L-guluronate) lyase.
Reaction catalysed
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at their reducing end
Comment(s)
  • The enzyme catalyzes the degradation of alginate by a beta- elimination reaction.
  • It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non- reducing ends and alpha-L-guluronate at the reducing end.
  • Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products.
  • Cf. EC 4.2.2.3.
Cross-references
BRENDA4.2.2.11
EC2PDB4.2.2.11
ExplorEnz4.2.2.11
PRIAM enzyme-specific profiles4.2.2.11
KEGG Ligand Database for Enzyme Nomenclature4.2.2.11
IUBMB Enzyme Nomenclature4.2.2.11
IntEnz4.2.2.11
MEDLINEFind literature relating to 4.2.2.11
MetaCyc4.2.2.11
Rhea expert-curated reactions4.2.2.11

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-