ENZYME

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ENZYME entry: EC 4.2.2.11

Accepted Name
guluronate-specific alginate lyase.
Alternative Name(s)
alginase II.
poly(alpha-L-guluronate) lyase.
Reaction catalysed
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at their reducing end
Comment(s)
The enzyme catalyzes the degradation of alginate by a beta- elimination reaction. It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non- reducing ends and alpha-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. Cf. EC 4.2.2.3.
Cross-references
BRENDA	4.2.2.11
EC2PDB	4.2.2.11
ExplorEnz	4.2.2.11
PRIAM enzyme-specific profiles	4.2.2.11
KEGG Ligand Database for Enzyme Nomenclature	4.2.2.11
IUBMB Enzyme Nomenclature	4.2.2.11
IntEnz	4.2.2.11
MEDLINE	Find literature relating to 4.2.2.11
MetaCyc	4.2.2.11
Rhea expert-curated reactions	4.2.2.11